Clinical Rheumatology

, Volume 28, Issue 1, pp 65–70

Risks factors for low bone mineral density in pre-menopausal Mexican women with systemic lupus erythematosus

Authors

  • Claudia Mendoza-Pinto
    • Systemic Autoimmune Diseases Research Unit, HGR 36, CMN Manuel Avila CamachoInstituto Mexicano del Seguro Social
  • Mario García-Carrasco
    • Systemic Autoimmune Diseases Research Unit, HGR 36, CMN Manuel Avila CamachoInstituto Mexicano del Seguro Social
    • Rheumatology Department, Medicine School of BenemeritaUniversidad Autónoma de Puebla
  • Hilda Sandoval-Cruz
    • Radiology Unit, HGR 36, CMN Manuel Avila CamachoInstituto Mexicano del Seguro Social
  • Ricardo O. Escárcega
    • Internal Medicine. Temple University Hospital
  • Mario Jiménez-Hernández
    • Systemic Autoimmune Diseases Research Unit, HGR 36, CMN Manuel Avila CamachoInstituto Mexicano del Seguro Social
    • Department of Autoimmune DiseasesInstitut Clínic de Medicina i Dermatologia, Hospital Clínic
  • Ivet Etchegaray-Morales
    • Systemic Autoimmune Diseases Research Unit, HGR 36, CMN Manuel Avila CamachoInstituto Mexicano del Seguro Social
  • Elena Soto-Vega
    • Systemic Autoimmune Diseases Research Unit, HGR 36, CMN Manuel Avila CamachoInstituto Mexicano del Seguro Social
  • Margarita Muñoz-Guarneros
    • Systemic Autoimmune Diseases Research Unit, HGR 36, CMN Manuel Avila CamachoInstituto Mexicano del Seguro Social
  • Aurelio López-Colombo
    • State Research DepartmentInstituto Mexicano del Seguro Social
  • Margarita Delezé-Hinojosa
    • Osteoporosis ClinicHospital Angeles
    • Department of Autoimmune DiseasesInstitut Clínic de Medicina i Dermatologia, Hospital Clínic
    • Servei de Malalties AutoimmunesHospital Clínic
Original Article

DOI: 10.1007/s10067-008-0984-z

Cite this article as:
Mendoza-Pinto, C., García-Carrasco, M., Sandoval-Cruz, H. et al. Clin Rheumatol (2009) 28: 65. doi:10.1007/s10067-008-0984-z

Abstract

The aim of this study was to determine the prevalence and risk factors for low bone mineral density (BMD) in women with systemic lupus erythematosus (SLE). A cross-sectional study was conducted among 100 pre-menopausal patients with SLE. Patients were evaluated using a questionnaire about the following variables: age, disease duration, disease activity, chronic disease damage, cumulative corticosteroid dose, and history of fracture. Lumbar spine and hip measurements of BMD were performed by dual absorptiometry. Univariate and multivariate statistical analyses were used to assess the relationship between risk factors and BMD. The mean age was 32.8 ± 8.7 years, and the median duration of SLE was 73.2 ± 65 months. The mean cumulative corticosteroid dose was 20.0 ± 21.3 g. The mean BMD was 1.09 ± .18 g/cm2 in the lumbar spine and 1.0 ± .14 g/cm2 in the hip. Osteopenia was present in 40% of patients and osteoporosis in 5%. In the multiple regression analysis, low BMD in the lumbar spine was associated with chronic disease damage and low body mass index (BMI). Low BMD in the hip was associated with cumulative corticosteroid dose and low BMI. Chronic disease damage, low BMI, and cumulative corticosteroid dose are risks factors for low BMD in pre-menopausal SLE patients. Osteopenia was found in 40% of patients, while osteoporosis was found in only 5%.

Keywords

Bone mineral densityOsteoporosisPre-menopausalSystemic lupus erythematosus

Copyright information

© Clinical Rheumatology 2008