Clinical Rheumatology

, Volume 27, Issue 6, pp 795–797

Effect of anti-TNF treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis

  • John Serelis
  • Meropi D. Kontogianni
  • Stergios Katsiougiannis
  • Maria Bletsa
  • Maria G. Tektonidou
  • Fotini N. Skopouli
Brief Report

DOI: 10.1007/s10067-008-0855-7

Cite this article as:
Serelis, J., Kontogianni, M.D., Katsiougiannis, S. et al. Clin Rheumatol (2008) 27: 795. doi:10.1007/s10067-008-0855-7

Abstract

The aim of this study was to investigate the effect of anti-tumor necrosis factor alpha (anti-TNF) treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis (RA). Nineteen women with RA starting anti-TNF treatment were included in the study. Disease activity, body composition, lumbar spine bone mineral density (BMD) and serum adiponectin concentrations were measured at baseline and after 1 year of follow-up. No important changes on body composition and lumbar spine BMD were observed, while the serum levels of adiponectin levels increased after 1 year of anti-TNF treatment (p = 0.02). Anti-TNF treatment in women with RA does not have any significant effect on body composition; however, it is associated with increase in adiponectin levels which may ameliorate the systemic inflammatory response state associated with RA.

Keywords

AdiponectinAnti-TNF treatmentBone mineral densityLean body massRheumatoid arthritis

Copyright information

© Clinical Rheumatology 2008

Authors and Affiliations

  • John Serelis
    • 1
  • Meropi D. Kontogianni
    • 2
  • Stergios Katsiougiannis
    • 2
  • Maria Bletsa
    • 2
  • Maria G. Tektonidou
    • 1
  • Fotini N. Skopouli
    • 1
    • 2
  1. 1.Department of Internal MedicineAthens EuroclinicAthensGreece
  2. 2.Department of Dietetics and Nutritional ScienceHarokopio UniversityAthensGreece