Clinical Rheumatology

, Volume 27, Issue 2, pp 201–205

Treatment of venous thrombosis associated with Behcet’s disease: immunosuppressive therapy alone versus immunosuppressive therapy plus anticoagulation

  • Joong Kyong Ahn
  • You Sun Lee
  • Chan Hong Jeon
  • Eun-Mi Koh
  • Hoon-Suk Cha
Original Article

DOI: 10.1007/s10067-007-0685-z

Cite this article as:
Ahn, J.K., Lee, Y.S., Jeon, C.H. et al. Clin Rheumatol (2008) 27: 201. doi:10.1007/s10067-007-0685-z

Abstract

The aim of this study was to compare the efficacy of immunosuppressive therapy alone with that of combination therapy involving immunosuppressants and anticoagulation for the treatment of venous thrombosis in Behcet’s disease (BD). A retrospective analysis was made of 37 patients with venous thrombosis in BD. BD patients with venous thrombosis were divided into three groups: one group (N = 16) received immunosuppressive therapy alone, another group (N = 17) received immunosuppressant and anticoagulation combination therapy, and the third group (N = 4) received anticoagulation therapy only. Clinical and laboratory parameters and the recurrence of venous thrombosis were assessed. Venous thrombosis in BD appeared to have a more diffuse pattern than idiopathic type and a predilection for lower limbs. The most commonly involved sites were the superficial and common femoral veins. Recurrence of venous thrombosis occurred in two cases in the immunosuppressant group (12.5%), one case in the combination therapy group (5.9%), and three cases in the anticoagulant group (75%). No significant difference was found between recurrence in the immunosuppressant and combination therapy groups. Acute phase reactants were elevated in all six patients at the time of venous thrombosis recurrence. Our study suggests that immunosuppressive therapy is essential and that anticoagulation therapy might not be required for the treatment of deep venous thrombosis associated with BD.

Keywords

AnticoagulationBehcet’s diseaseDeep venous thrombosisImmunosuppression

Copyright information

© Clinical Rheumatology 2007

Authors and Affiliations

  • Joong Kyong Ahn
    • 1
  • You Sun Lee
    • 1
  • Chan Hong Jeon
    • 2
  • Eun-Mi Koh
    • 1
  • Hoon-Suk Cha
    • 1
  1. 1.Department of Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea
  2. 2.Department of Internal MedicineSoonchunhyang University College of MedicineGyeonggi-doSouth Korea