Clinical Rheumatology

, Volume 26, Issue 8, pp 1312–1319

Analgesic activity of a polysaccharide in experimental osteoarthritis in rats

  • Rondinelle Ribeiro Castro
  • Judith Pessoa Andrade Feitosa
  • Pablyana Leila Rodrigues da Cunha
  • Francisco Airton Castro da Rocha
Original Article

DOI: 10.1007/s10067-006-0506-9

Cite this article as:
Castro, R.R., Feitosa, J.P.A., da Cunha, P.L.R. et al. Clin Rheumatol (2007) 26: 1312. doi:10.1007/s10067-006-0506-9

Abstract

Viscosupplementation efficacy has been related to the high molecular weight of hyaluronic acid-like compounds, as well as to gel formulation. We evaluated the effect of a galactomannan polysaccharide derived from Guar gum (GG) in joint pain in an osteoarthritis (OA) model. Wistar rats (six animals/group) were subjected to anterior cruciate ligament transection (ACLT-OA group). The OA group was compared to a false-operated group (sham). Joint pain was recorded daily, using the articular incapacitation test, until 7 days after ACLT. Solutions or gel preparations of GG (100 μg) or Hylan G-F 20 (100 μg), used as a comparator, were given intraarticularly (i.a.) at day 4 after ACLT. Controls received saline i.a. The OA group had significantly increased joint pain as compared to sham (P < 0.001). GG, either as a gel or solution, significantly inhibited joint pain similar to the inhibition achieved with Hylan G-F20. This is the first demonstration that a galactomannan derived from GG reduces joint pain in experimental OA. This analgesia is independent of the colloidal state. We propose that the analgesic benefit of viscosupplementation may be due to an intrinsic carbohydrate-mediated mechanism rather than to the rheologic properties of the material.

Keywords

Joint painOsteoarthritisPolysaccharideViscosupplementation

Copyright information

© Clinical Rheumatology 2007

Authors and Affiliations

  • Rondinelle Ribeiro Castro
    • 1
  • Judith Pessoa Andrade Feitosa
    • 2
  • Pablyana Leila Rodrigues da Cunha
    • 2
  • Francisco Airton Castro da Rocha
    • 4
  1. 1.Department of Physiology and PharmacologyFederal University of CearáFortalezaBrazil
  2. 2.Department of Organic and Inorganic ChemistryFederal University of CearáFortalezaBrazil
  3. 3.Department of Organic and Inorganic ChemistryFederal University of CearáFortalezaBrazil
  4. 4.Department of Internal MedicineFederal University of CearáFortalezaBrazil