Clinical Rheumatology

, Volume 26, Issue 6, pp 927–929

SAA1 α/α alleles in Behçet’s disease related amyloidosis

  • Umut Utku
  • Melda Dilek
  • Ilkser Akpolat
  • Abdülkerim Bedir
  • Tekin Akpolat
Original Article

DOI: 10.1007/s10067-006-0435-7

Cite this article as:
Utku, U., Dilek, M., Akpolat, I. et al. Clin Rheumatol (2007) 26: 927. doi:10.1007/s10067-006-0435-7

Abstract

Behçet’s disease (BD) related amyloidosis is relatively rare. Serum amyloid A protein (SAA) protein gene polymorphism is one of the factors implicated in the pathogenesis of AA type amyloidosis. The aim of this study is to investigate SAA1 gene polymorphism in different patient groups: (1) BD related amyloidosis, (2) BD without amyloidosis, and (3) healthy controls. One hundred eleven patients from three main groups were included in the study: (1) BD related amyloidosis (n = 9), (2) BD without amyloidosis (n = 39), and (3) healthy controls (n = 63). Homozygous α/α is present in 78% of patients with BD and amyloidosis. The SAA1 α/α genotype is significantly more common among patients with BD and amyloidosis. This study demonstrated increased frequency of α/α genotype in BD related amyloidosis. To our knowledge, the relationship between α/α genotype and BD related amyloidosis was not studied previously. In conclusion, the SAA1 α/α genotype is a risk factor for amyloidosis in BD.

Keywords

AmyloidosisBehçet’s diseaseSAA1 allele

Copyright information

© Clinical Rheumatology 2006

Authors and Affiliations

  • Umut Utku
    • 1
  • Melda Dilek
    • 1
  • Ilkser Akpolat
    • 1
  • Abdülkerim Bedir
    • 1
  • Tekin Akpolat
    • 1
  1. 1.Ondokuz Mayıs ÜniversitesiSamsunTurkey