Clinical Rheumatology

, Volume 25, Issue 6, pp 929–933

New-onset demyelination induced by infliximab therapy in two rheumatoid arthritis patients

  • Makoto Tanno
  • Ichiro Nakamura
  • Shunsuke Kobayashi
  • Kumiko Kurihara
  • Katsumi Ito
Case Report

DOI: 10.1007/s10067-005-0097-x

Cite this article as:
Tanno, M., Nakamura, I., Kobayashi, S. et al. Clin Rheumatol (2006) 25: 929. doi:10.1007/s10067-005-0097-x

Abstract

Therapies aimed at inhibiting tumor necrosis factor, a proinflammatory cytokine implicated in autoimmune disease, are effective for rheumatoid arthritis (RA) and Crohn’s disease. We report two patients who newly developed multiple demyelinating lesions in the central nervous system in the course of infliximab therapy for active RA. Neurological symptoms and the number of gadolinium-diethylenetriamine pentaacetic acid-enhanced lesions in magnetic resonance imaging gradually diminished with steroid treatment.

Keywords

Demyelinating Infliximab Magnetic resonance imaging (MRI) Multiple sclerosis Rheumatoid arthritis Tumor necrosis factor 

Copyright information

© Clinical Rheumatology 2005

Authors and Affiliations

  • Makoto Tanno
    • 1
  • Ichiro Nakamura
    • 1
  • Shunsuke Kobayashi
    • 2
  • Kumiko Kurihara
    • 3
  • Katsumi Ito
    • 1
  1. 1.Department of RheumatologyYugawara Kosei-Nenkin HospitalKanagawaJapan
  2. 2.Department of Neurology, Division of Neuroscience, Graduate School of MedicineUniversity of TokyoTokyoJapan
  3. 3.Department of OphthalmologyYugawara Kosei-Nenkin HospitalKanagawaJapan