, Volume 25, Issue 5, pp 749-752
Date: 25 Oct 2005

Rasburicase treatment in severe tophaceous gout: a novel therapeutic option

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Abstract

We recently encountered a destructive case of tophaceous gout in a 57-year-old patient. Despite perfect therapy compliance, the patient failed in the conventional urate-lowering treatment, accounting for the ongoing urate retention and accumulation with progressive tophaceous bulky disease. Application of an experimental scheme of uricolytical therapy on this patient was able to reduce bulky disease significantly. In modern medicine, potent urate-debulking medication with urate oxidase (uricase) derivatives is at our disposal, and it is a challenge for rheumatologists to install the right strategy including innovative approaches with potent uricolytic therapy on the right patient at the right time.

The presented case has been published before in a local Dutch mailing for rheumatologists.