Abnormalities in the bone mineral metabolism in HIV-infected patients
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
To evaluate bone mineral metabolism in HIV infected and asymptomatic patients receiving highly active antiretroviral therapy (HAART) containing protease inhibitors (PI) and naïve patients.
We studied 30 asymptomatic HIV infected male patients, 13 in the naive group and 17 in the IP group, both without differences in demographics characteristics. We excluded women and patients with any known factor associated to osteopenia. We did a nutritional questionnaire, a DEXA scan in lumbar spine and femur, a study of CD4 lymphocytes, viral load and an analysis of bone formation and resorption markers in all patients. We compared vitamin D and PTH levels with a control group of healthy male volunteers age-pareated. For the statistical analysis we used the SPSS program.
Osteopenia was present in 17/30 (57%), 8/13 (61.5%) in the naïve group and 9/17 (53%) in the PI group (not significant differences). We found a vitamin D deficiency in 86% of patients, with mean serum levels that was found to be significantly lower than those from a healthy control group (p=0.04). Testosterone level was significantly related to bone mineral density in lumbar spine (p≤0.05).
HIV may be an individual risk factor in bone disorders, requiring calcium and vitamin D supplementation.
- Kuhne, C, Heufelder, A, Hofbauer, L (2001) Bone and mineral metabolism in human immunodeficiency virus infection. J Bone Miner Res 16: pp. 2-9 CrossRef
- Carr, A, Samaras, K, Chisholm, DJ, Cooper, DA (1998) Abnormal fat distribution and use of protease inhibitors. Lancet 351: pp. 1736 CrossRef
- Nolan, D, Upton, R, McKinnon, E, John, M, James, I, Adler, B (2001) Stable or increasing bone mineral density in HIV-infected patients treated with nelfinavir or indinavir. AIDS 15: pp. 1275-1280 CrossRef
- Tebas, P, Powderly, GW, Claxton, S, Marin, D, Tantisiriwat, W, Teitelbaum, LS (2000) Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy. AIDS 14: pp. F63-F67 CrossRef
- Bruera, D, David, DO, Bergoglio, LM, Zumudio, J (2003) Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy. AIDS 17: pp. 1917-1923 CrossRef
- Cozzolino, M, Vidal, M, Arcidiacono, MV, Tebas, P, Yarasheski, K, Dusso, A (2003) HIV-protease inhibitors impair vitamin D bioactivation to 1,25-dihydroxyvitamin D. AIDS 17: pp. 513-520 CrossRef
- Haug, C, Aukrust, P, Haug, E, Morkrid, L, Muller, F, Froland, S (1998) Severe deficiency of 1,25-dihydroxyvitamin D3 in human immunodeficiency virus infection: association with immunological hyperactivity and only minor changes in calcium homeostasis. J Clin Endocrinol Metab 83: pp. 3832-3838 CrossRef
- McKenna, MJ (1992) Differences in vitamin D status between countries in young adults and the elderly. Am J Med 93: pp. 69-77 CrossRef
- Aguado, P, Garcés, MV, Gonzalez Casaus, ML, Campo, MT, Rich, J, Torrijos, A (2000) High prevalence of vitamin D deficiency in postmenopausal women at a rheumatology office in Madrid. Evaluation of 2 vitamin D prescription regimens. Med Clin (Barc) 114: pp. 326-330
- Lips, P, Duong, T, Oleksik, A, Black, D, Cummings, S, Cox, D (2001) A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab 86: pp. 1212-1221 CrossRef
- Bandeira, F, Caldas, G, Freese, E, Griz, L, Faria, M, Bandeira, C (2002) Relationship between serum vitamin D status and clinical manifestations of primary hyperparathyroidism. Endocr Pract 8: pp. 266-270
- Abnormalities in the bone mineral metabolism in HIV-infected patients
Volume 25, Issue 4 , pp 537-539
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Vitamin D
- Industry Sectors
- Author Affiliations
- 1. Rheumatology Unit, Hospital Virgen de la Salud, Avenida Barber, 30, Toledo, 45004, Spain
- 2. Rheumatology Unit, Hospital Universitario La Paz, Madrid, Spain
- 3. Internal Medicine, Hospital Universitario La Paz, Madrid, Spain
- 4. Biochemistry Unit, Hospital Universitario La Paz, Madrid, Spain
- 5. Nuclear Medicine, Hospital Universitario La Paz, Madrid, Spain