, Volume 23, Issue 6, p 566
Date: 02 Jun 2004

Endotoxin as a factor for joint pain and rheumatoid arthritis

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Luosujärvi et al. [1] reported on joint symptoms in a small population that was exposed to high levels of moisture in a building. Microbes, specifically mold, were observed growing under the flooring materials and were suggested as a potential cause for the observed increased incidence in joint pain and rheumatoid arthritis (RA). What is not mentioned as a factor is endotoxin (lipopolysaccharide), which is a component of gram-negative bacteria and a common contaminate in moisture damaged buildings [2]. Endotoxin has been suggested to be a causative agent of joint inflammation [3] and may be one of the causes of RA observed in this study.