Clinical Rheumatology

, Volume 22, Issue 6, pp 397–399

Synovial fluid nitric oxide levels in patients with knee osteoarthritis

  • Ayşe Karan
  • Mehmet Akif Karan
  • Pervin Vural
  • Nilgün Erten
  • Cemil Taşçıoğlu
  • Cihan Aksoy
  • Mukaddes Canbaz
  • Ahmet Öncel
Original Article

DOI: 10.1007/s10067-003-0761-y

Cite this article as:
Karan, A., Karan, M.A., Vural, P. et al. Clin Rheumatol (2003) 22: 397. doi:10.1007/s10067-003-0761-y

Abstract

Nitric oxide (NO) has an important role in the inflammatory arthropathies. This study investigated NO levels in the synovial fluid and plasma of patients with primary osteoarthritis (OA) of the knee. Twenty-seven cases with primary knee OA and 13 controls were recruited for the study. Nitrate/nitrite levels of synovial fluid and plasma were measured by Griess reaction, and interleukin-1β (IL-1β) levels were measured quantitatively by a sandwich immunoassay technique. We found a significant increase in the synovial fluid nitrate/nitrite levels in cases with primary OA of the knee compared to controls (50.26±23.63 μg/l vs 32.49±10.05 μg/l, p=0.002) as well as increased plasma nitrate/nitrite levels (57.06±23.32 μg/l vs 39.98±16.36 μg/l, p=0.012). There was no difference in plasma and synovial fluid IL-1β concentrations between the study and control groups. These results may be considered as supporting evidence that NO might be one of the factors responsible for cartilage destruction in primary osteoarthritis of the knee.

Keywords

Interleukin-1βNitric oxideOsteoarthritis

Abbreviations

NO

Nitric oxide

OA

Osteoarthritis

TMJ

Temporomandibular joint

Copyright information

© Clinical Rheumatology 2003

Authors and Affiliations

  • Ayşe Karan
    • 1
  • Mehmet Akif Karan
    • 1
  • Pervin Vural
    • 1
  • Nilgün Erten
    • 1
  • Cemil Taşçıoğlu
    • 1
  • Cihan Aksoy
    • 1
  • Mukaddes Canbaz
    • 1
  • Ahmet Öncel
    • 1
  1. 1.Istanbul UniversityIstanbulTurkey