Clinical Rheumatology

, Volume 22, Issue 3, pp 234–236

Autoimmune hepatitis in a patient with systemic lupus erythematosus

  • M. Iwai
  • Y. Harada
  • M. Ishii
  • S. Tanaka
  • A. Muramatsu
  • T. Mori
  • T. Nakashima
  • T. Okanoue
  • S. Hirohata
Article

DOI: 10.1007/s10067-002-0689-7

Cite this article as:
Iwai, M., Harada, Y., Ishii, M. et al. Clin Rheumatol (2003) 22: 234. doi:10.1007/s10067-002-0689-7

Abstract

We report a female patient with systemic lupus erythematous (SLE), hyperbilirubinemia and high serum value of ALT. International autoimmune hepatitis (AIH) score showed definite AIH before treatment, but autoantibodies could not make a differential diagnosis of AIH and SLE-associated hepatitis. Liver biopsy showed periportal hepatitis with lymphoplasmacytic infiltration, but neither parenchymal collapse nor rosette formation could be found. Pericarditis, pleuritis and nephritis were improved as well as liver injury after administration of prednisolone, and no repeated attack has been present these 4 years. Our case suggested invalidity of AIH score among patients of SLE, and liver histology should be inferred most important at present to make a differential diagnosis of lupus hepatitis or AIH in patients with SLE.

Keywords

Autoimmune hepatitis International AIH score Liver histology Lupus hepatitis Systemic lupus erythematosus 

Copyright information

© Clinical Rheumatology 2003

Authors and Affiliations

  • M. Iwai
    • 1
    • 3
  • Y. Harada
    • 1
  • M. Ishii
    • 1
  • S. Tanaka
    • 1
  • A. Muramatsu
    • 1
  • T. Mori
    • 1
  • T. Nakashima
    • 1
  • T. Okanoue
    • 1
  • S. Hirohata
    • 2
  1. 1.Kyoto Prefectural University of MedicineJapan
  2. 2.Teikyo University of MedicineTokyoJapan
  3. 3.Third Department of Internal MedicineKyoto Prefectural University of MedicineKyotoJapan