Molecules and Cells

, Volume 36, Issue 4, pp 279–287

Metabolic roles of AMPK and metformin in cancer cells

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DOI: 10.1007/s10059-013-0169-8

Cite this article as:
Choi, Y.K. & Park, KG. Mol Cells (2013) 36: 279. doi:10.1007/s10059-013-0169-8

Abstract

Metformin is one of the most widely used anti-diabetic agents in the world, and a growing body of evidence suggests that it may also be effective as an anti-cancer drug. Observational studies have shown that metformin reduces cancer incidence and cancer-related mortality in multiple types of cancer. These results have drawn attention to the mechanisms underlying metformin’s anti-cancer effects, which may include triggering of the AMP-activated protein kinase (AMPK) pathway, resulting in vulnerability to an energy crisis (leading to cell death under conditions of nutrient deprivation) and a reduction in circulating insulin/IGF-1 levels. Clinical trials are currently underway to determine the benefits, appropriate dosage, and tolerability of metformin in the context of cancer therapy. This review highlights fundamental aspects of the molecular mechanisms underlying metformin’s anti-cancer effects, describes the epidemiological evidence and ongoing clinical challenges, and proposes directions for future translational research.

Keywords

AMPK cancer LKB1 metformin 

Copyright information

© The Korean Society for Molecular and Cellular Biology and Springer Netherlands 2013

Authors and Affiliations

  1. 1.Division of Endocrinology and Metabolism, Department of Internal MedicineKyungpook National University School of MedicineDaeguKorea