Molecules and Cells

, Volume 29, Issue 4, pp 355–361

Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation

  • Markus Plate
  • Ting Li
  • Yu Wang
  • Xiaoning Mo
  • Yingmei Zhang
  • Dalong Ma
  • Wenling Han
Article

DOI: 10.1007/s10059-010-0038-7

Cite this article as:
Plate, M., Li, T., Wang, Y. et al. Mol Cells (2010) 29: 355. doi:10.1007/s10059-010-0038-7

Abstract

Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.

Keywords

apoptosiscell cyclecell growthCMTM4MARVEL

Copyright information

© The Korean Society for Molecular and Cellular Biology and Springer Netherlands 2010

Authors and Affiliations

  • Markus Plate
    • 1
  • Ting Li
    • 1
  • Yu Wang
    • 1
  • Xiaoning Mo
    • 1
  • Yingmei Zhang
    • 1
  • Dalong Ma
    • 1
  • Wenling Han
    • 1
  1. 1.Center for Human Disease Genomics, Department of Immunology, School of Basic Medical Science, Health Science CenterPeking UniversityBeijingChina