Molecules and Cells

, Volume 28, Issue 1, pp 7–12

Biology of glioma cancer stem cells


    • University of Pittsburgh Cancer Institute
    • Department of Neurological SurgeryUniversity of Pittsburgh
    • Department of Pharmacology and Chemical BiologyUniversity of Pittsburgh
  • Jeremy N. Rich
    • Department of Stem Cell Biology and Regenerative MedicineCleveland Clinic

DOI: 10.1007/s10059-009-0111-2

Cite this article as:
Park, D.M. & Rich, J.N. Mol Cells (2009) 28: 7. doi:10.1007/s10059-009-0111-2


Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for in vitro and in vivo growth, a property intimately linked to the cell’s differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the so-called glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.


brain tumorcancer stem cellgliomaglioblastoma

Copyright information

© The Korean Society for Molecular and Cellular Biology and Springer Netherlands 2009