Neurogenetics

, Volume 3, Issue 2, pp 69–78

Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress

  • Carlton A.W. Evans
  • Michael S. Harbuz
  • Thor Ostenfeld
  • Alan Norrish
  • Jenefer M. Blackwell
Original Article

DOI: 10.1007/s100480100105

Cite this article as:
Evans, C., Harbuz, M., Ostenfeld, T. et al. Neurogenetics (2001) 3: 69. doi:10.1007/s100480100105

Abstract

The gene Nramp1 encoding the natural resistance-associated macrophage protein (Nramp1) influences susceptibility to intracellular infections and autoimmune diseases, and the humoral response to stress. Nramp1 functions as a proton/divalent cation antiporter in the membranes of late endosomes/lysosomes, regulating cytoplasmic iron levels in macrophages. The Drosophila homologue of Nramp1 is expressed in sensory neurons and macrophages, and influences taste behaviour directly through divalent cation transport. Here we demonstrate that murine Nramp1 is also expressed on neurons as well as microglial cells in the brain and influences the behavioural response to stress, hypothalamus-pituitary-adrenal (HPA) axis activation and mortality following Toxoplasma gondii infection in control and pre-stressed mice. We hypothesise that, although differences in HPA activation translate into differences in adrenal enlargement and basal circulating corticosterone levels, the primary influence of Nramp1 is at the level of the neuronal response to stress. These results provide new insight into the possible roles of divalent cation transporters of the Nramp gene family in regulating metal ion homeostasis in the brain and its pathological implications.

Divalent cation transporter Hypothalamus-pituitary-adrenal axis Toxoplasma Corticotrophin releasing hormone Corticosterone 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Carlton A.W. Evans
    • 1
  • Michael S. Harbuz
    • 2
  • Thor Ostenfeld
    • 3
  • Alan Norrish
    • 1
  • Jenefer M. Blackwell
    • 1
  1. 1.Wellcome Trust Centre for Molecular Mechanisms in Disease, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge, CB2 2XY, UKUK
  2. 2.URC Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, Bristol, BS2 8HW, UKUK
  3. 3.MRC Centre for Brain Repair, University of Cambridge, Forvie Site, Cambridge, CB2 2PY, UKUK

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