Neurogenetics

, Volume 2, Issue 2, pp 129–131

5-HTTLPR variants not associated with autistic spectrum disorders

  • N. Zhong
  • L. Ye
  • W. Ju
  • J. Tsiouris
  • I. Cohen
  • W. T. Brown
Short Communication

DOI: 10.1007/s100480050064

Cite this article as:
Zhong, N., Ye, L., Ju, W. et al. Neurogenetics (1999) 2: 129. doi:10.1007/s100480050064

To determine whether there is an association of polymorphic variants of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) and autistic spectrum disorders, we analyzed the 5-HTTLPR genotypes of 72 autistic subjects, 11 fragile X syndrome patients with autistic behavior, 43 normal subjects, and 49 fragile X syndrome non-autistic subjects. The distribution frequency of 5-HTTLPR long allele (L) and the short allele (S) variants showed no differences between subjects. Our findings do not support the hypothesis that polymorphic 5-HTTLPR variants are a susceptibility factor for autistic disorders.

Key words Autism Serotonin transporter Genotypes Polymorphism Fragile X syndrome 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • N. Zhong
    • 1
  • L. Ye
    • 1
  • W. Ju
    • 1
  • J. Tsiouris
    • 2
  • I. Cohen
    • 2
  • W. T. Brown
    • 1
  1. 1.Department of Human Genetics, New York State Institute for Basic Research, 1050 Forest Hill Road, Staten Island, NY 10314, USA Tel: +1-718-494-5242; Fax: +1-718-494–1026 e-mail: omrddzhong@aol.comIS
  2. 2.George A. Jervis Clinic, New York State Institute for Basic Research, Staten Island, NY 10314, USAIS

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