, Volume 11, Issue 3, pp 275–290

RNA processing pathways in amyotrophic lateral sclerosis


DOI: 10.1007/s10048-010-0239-4

Cite this article as:
van Blitterswijk, M. & Landers, J.E. Neurogenetics (2010) 11: 275. doi:10.1007/s10048-010-0239-4


RNA processing is a tightly regulated, highly complex pathway which includes RNA transcription, pre-mRNA splicing, editing, transportation, translation, and degradation of RNA. Over the past few years, several RNA processing genes have been shown to be mutated or genetically associated with amyotrophic lateral sclerosis (ALS), including the RNA-binding proteins TDP-43 and FUS/TLS. These findings suggest that RNA processing may represent a common pathogenic mechanism involved in development of ALS. In this review, we will discuss six ALS-related, RNA processing genes including their discovery, function, and commonalities.


Amyotrophic lateral sclerosisMutationRNA processingTranscriptionSplicing

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of Massachusetts Medical SchoolWorcesterUSA
  2. 2.Department of NeurologyUniversity Medical Center UtrechtUtrechtThe Netherlands