Neurogenetics

, Volume 5, Issue 3, pp 177–185

A G301R Na+/K+-ATPase mutation causes familial hemiplegic migraine type 2 with cerebellar signs

Authors

  • Maria Spadaro
    • Department of Neurological Sciences, 1st Medical SchoolLa Sapienza University
  • Simona Ursu
    • Department of Applied PhysiologyUlm University
  • Frank Lehmann-Horn
    • Department of Applied PhysiologyUlm University
  • Veneziano Liana
    • Institute of Neurobiology and Molecular Medicine CNR
  • Antonini Giovanni
    • Department of Neurological Sciences, 1st Medical SchoolLa Sapienza University
  • Giunti Paola
    • Institute of NeurologyUniversity College
  • Marina Frontali
    • Institute of Neurobiology and Molecular Medicine CNR
    • Department of Applied PhysiologyUlm University
Original Article

DOI: 10.1007/s10048-004-0183-2

Cite this article as:
Spadaro, M., Ursu, S., Lehmann-Horn, F. et al. Neurogenetics (2004) 5: 177. doi:10.1007/s10048-004-0183-2

Abstract.

Familial hemiplegic migraine (FHM) is an autosomal dominant subtype of migraine with hemiparesis during the aura. In over 50% of cases the causative gene is CACNA1A (FHM1), which in some cases produces a phenotype with cerebellar signs, including ataxia and nystagmus. Recently, mutations in ATP1A2 on chromosome 1q23 encoding a Na+/K+-ATPase subunit were identified in four families (FHM2). We now describe an FHM2 pedigree with a fifth ATP1A2 mutation coding for a G301R substitution. The phenotype was particularly severe and included hemiplegic migraine, seizure, prolonged coma, elevated temperature, sensory deficit, and transient or permanent cerebellar signs, such as ataxia, nystagmus, and dysarthria. A mild crossed cerebellar diaschisis during an attack further supported the clinical evidence of a cerebellar deficit. This is the first report suggesting cerebellar involvement in FHM2. A possible role for CACNA1A in producing the phenotype in this family was excluded by linkage studies to the FHM1 locus. The study of this family suggests that the absence of cerebellar signs may not be a reliable indicator to clinically differentiate FHM2 from FHM1.

Keywords

Hemiplegic migraineCerebellar diachisisATP1A2FHM2 mutation

Copyright information

© Springer-Verlag 2004