, Volume 5, Issue 1, pp 1–8

Friedreich ataxia—update on pathogenesis and possible therapies

Review Article

DOI: 10.1007/s10048-003-0170-z

Cite this article as:
Voncken, M., Ioannou, P. & Delatycki, M.B. Neurogenetics (2004) 5: 1. doi:10.1007/s10048-003-0170-z


Friedreich ataxia is the most-common inherited ataxia. Since the causative genetic basis was described in 1996, much has been learnt about the pathogenesis from human, animal, and yeast studies. This has led to the development of rational therapeutic approaches. In this review, the current state of knowledge regarding the pathogenesis of Friedreich ataxia is presented and possible therapeutic strategies based on this knowledge are discussed.


Friedreich ataxiaPathogenesisTherapeutic strategies

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Max Voncken
    • 1
    • 2
  • Panos Ioannou
    • 2
    • 3
  • Martin B. Delatycki
    • 2
    • 3
    • 4
  1. 1.Department of Cellular Animal Physiology, Subfaculty of Biology, Faculty of ScienceUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Murdoch Childrens Research InstituteRoyal Children’s HospitalParkvilleAustralia
  3. 3.Department of Pediatrics, University of MelbourneRoyal Children’s HospitalParkvilleAustralia
  4. 4.Bruce Lefroy Centre for Genetic Health Research, Genetic Health Services VictoriaRoyal Children’s HospitalParkvilleAustralia