Journal of Artificial Organs

, Volume 16, Issue 2, pp 119–128

Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models

Authors

    • Department of Cardiothoracic SurgeryThe University of Tokyo
    • Department of Artificial OrganNational Cerebral and Cardiovascular Center
    • Department of Cardiothoracic SurgeryThe University of Tokyo
    • Department of Therapeutic Strategy for Heart FailureThe University of Tokyo
    • Department of Cardiothoracic SurgeryTokyo Metropolitan Geriatric Hospital
  • Yoshiaki Takewa
    • Department of Artificial OrganNational Cerebral and Cardiovascular Center
  • Masahiko Ando
    • Department of Cardiothoracic SurgeryThe University of Tokyo
  • Mamoru Arakawa
    • Department of Artificial OrganNational Cerebral and Cardiovascular Center
  • Yuichiro Kishimoto
    • Department of Artificial OrganNational Cerebral and Cardiovascular Center
  • Tomonori Tsukiya
    • Department of Artificial OrganNational Cerebral and Cardiovascular Center
  • Toshihide Mizuno
    • Department of Artificial OrganNational Cerebral and Cardiovascular Center
  • Shunei Kyo
    • Department of Cardiothoracic SurgeryThe University of Tokyo
    • Department of Therapeutic Strategy for Heart FailureThe University of Tokyo
    • Department of Cardiothoracic SurgeryTokyo Metropolitan Geriatric Hospital
  • Minoru Ono
    • Department of Cardiothoracic SurgeryThe University of Tokyo
  • Yoshiyuki Taenaka
    • Department of Artificial OrganNational Cerebral and Cardiovascular Center
  • Eisuke Tatsumi
    • Department of Artificial OrganNational Cerebral and Cardiovascular Center
Original Article

DOI: 10.1007/s10047-012-0682-0

Cite this article as:
Umeki, A., Nishimura, T., Takewa, Y. et al. J Artif Organs (2013) 16: 119. doi:10.1007/s10047-012-0682-0

Abstract

Aiming the ‘Bridge to Recovery’ course, we have developed a novel left ventricular assist device (LVAD) controlling system. It can change the rotational speed of the continuous flow LVAD, EVAHEART, synchronized with the cardiac beat. Employing this system, we have already demonstrated that myocardial oxygen consumption (MVO2), which is considered to be equivalent to native heart load, changes in the hearts of normal goats. Herein, we examined changes in goats with acute ischemic heart failure. We studied 14 goats (56.1 ± 6.9 kg) with acute ischemic heart failure due to coronary microsphere embolization. We installed the EVAHEART and drive in four modes: “circuit-clamp”, “continuous support”, “counter-pulse”, and “co-pulse”, with 50 and 100 % bypass. In comparison to the circuit-clamp mode, MVO2 was reduced to 70.4 ± 17.9 % in the counter-pulse mode and increased to 90.3 ± 14.5 % in the co-pulse mode, whereas it was 80.0 ± 14.5 % in the continuous mode, with 100 % bypass (p < 0.05). The same difference was confirmed with 50 % bypass. This means that we may have a chance to change the native heart load by controlling the LVAD rotation in synchrony with the cardiac rhythm, so we named our controller as the Native Heart Load Control System (NHLCS). Employing changeable MVO2 with NHLCS according to the patient’s condition may provide more opportunity for native heart recovery with LVAD, especially for patients with ischemic heart diseases.

Keywords

Continuous-flow LVADNHLCSMyocardial oxygen consumptionSynchronized with cardiac beat

Copyright information

© The Japanese Society for Artificial Organs 2013