Clinical trial of allogeneic cultured dermal substitutes for intractable skin ulcers of the lower leg

  • Naoto Yamada
  • Eiju Uchinuma
  • Yoshimitsu Kuroyanagi
Case Report

DOI: 10.1007/s10047-008-0406-7

Cite this article as:
Yamada, N., Uchinuma, E. & Kuroyanagi, Y. J Artif Organs (2008) 11: 100. doi:10.1007/s10047-008-0406-7

Abstract

The efficacy of allogeneic cultured dermal substitute (CDS) on wound healing was evaluated in six patients with intractable skin ulcers on the lower extremities. Allogeneic CDS was repeatedly applied to wounds at intervals of 4–7 days to prepare a wound bed acceptable for skin grafting or to induce resurfacing through the granulation tissue formation associated with epithelialization. In one patient with a leg ulcer, the wound size decreased to 32% of the original size within 10 weeks and skin grafting was conducted. In the other five patients with leg, ankle, or foot ulcers, the wound size decreased to 9%–25% of the original size within 6 weeks.

Key words

Allogeneic cultured dermal substitutesFibroblastSkin ulcer

Copyright information

© The Japanese Society for Artificial Organs 2008

Authors and Affiliations

  • Naoto Yamada
    • 1
  • Eiju Uchinuma
    • 1
  • Yoshimitsu Kuroyanagi
    • 2
  1. 1.Department of Plastic and Aesthetic SurgeryKitasato University School of MedicineSagamiharaJapan
  2. 2.Research and Development Center for Artificial SkinKitasato University School of Allied Health SciencesSagamiharaJapan