Journal of Artificial Organs

, Volume 9, Issue 3, pp 130–135

Present status and perspectives of bioartificial kidneys

  • Akira Saito
  • Tun Aung
  • Koji Sekiguchi
  • Yoshinobu Sato
  • Duc M. Vu
  • Miho Inagaki
  • Genta Kanai
  • Reika Tanaka
  • Hajime Suzuki
  • Takatoshi Kakuta
REVIEW

DOI: 10.1007/s10047-006-0336-1

Cite this article as:
Saito, A., Aung, T., Sekiguchi, K. et al. J Artif Organs (2006) 9: 130. doi:10.1007/s10047-006-0336-1

Abstract

Currently, hemodialysis is not adequate as a renal replacement therapy because it provides intermittent treatment and does not provide the metabolic function of renal tubules. The next generation of artificial kidney should replace intermittent hemodialysis with continuous hemofiltration and provide the full metabolic function of renal tubules. The current decade has witnessed the development of bioartificial kidneys using artificial membranes and renal tubular epithelial cells. Active transport and metabolic functions were confirmed in the confluent monolayers of tubular cells on artificial membranes. Bioartificial kidneys have succeeded in improving the prognosis of patients with multiple organ dysfunction, presumably by lowering plasma cytokine levels in patients. For successful treatment of chronic renal failure using bioartificial kidneys, it is necessary to overcome some technical hurdles such as improving the antithrombogenic properties of the surface of artificial membranes and prolonging the function of renal tubule cells on an artificial membrane. Transfection of functional protein genes into renal tubule cells enables bioartificial tubule devices to increase their transport capacity and metabolic functions such as digoxin secretion and water transport. The development of wearable roller pumps is also essential for the clinical application of a continuous treatment system.

Key words

Bioartificial kidney Tubular epithelial cells Artificial membrane Active transport Aquaporin Digoxin Multiple organ failure 

Copyright information

© The Japanese Society for Artificial Organs 2006

Authors and Affiliations

  • Akira Saito
    • 1
  • Tun Aung
    • 1
  • Koji Sekiguchi
    • 1
  • Yoshinobu Sato
    • 1
  • Duc M. Vu
    • 1
  • Miho Inagaki
    • 1
  • Genta Kanai
    • 1
  • Reika Tanaka
    • 1
  • Hajime Suzuki
    • 1
  • Takatoshi Kakuta
    • 1
  1. 1.Division of Nephrology, Department of MedicineTokai University School of MedicineBohseidai, IseharaJapan

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