Optical Review

, Volume 10, Issue 5, pp 466–469

Measurement of Cerebral Optical Pathlength as a Function of Oxygenation Using Near-infrared Time-resolved Spectroscopy in a Piglet Model of Hypoxia

Authors

    • Maternal Perinatal CenterKagawa Medical University
  • Yoshio Hisamatsu
    • Department of PediatricsKagawa Medical University
  • Kou Kawada
    • Maternal Perinatal CenterKagawa Medical University
  • Kensuke Okubo
    • Department of PediatricsKagawa Medical University
  • Hitoshi Okada
    • Department of PediatricsKagawa Medical University
  • Masanori Namba
    • Department of PediatricsKagawa Medical University
  • Tadashi Imai
    • Department of PediatricsKagawa Medical University
  • Kenichi Isobe
    • Department of PediatricsKagawa Medical University
  • Susumu Itoh
    • Department of PediatricsKagawa Medical University
ENVIRONMENTAL, BIOLOGICAL, AND SPACE OPTICS

DOI: 10.1007/s10043-003-0466-0

Cite this article as:
Kusaka, T., Hisamatsu, Y., Kawada, K. et al. OPT REV (2003) 10: 466. doi:10.1007/s10043-003-0466-0

Abstract

Near-infrared spectroscopy (NIRS) has been used for measurement of changes in cerebral hemoglobin concentrations in neonates to study cerebral oxygenation and hemodynamics. In this study, measurements by time-resolved reflectance spectroscopy (TRS) were performed in a piglet model with various degrees of cerebral oxygenation to estimate the differential pathlength factor (DPF). A portable three-wavelength TRS system (TRS-10, Hamamatsu Photonics K.K.) with a probe attached to the head of a piglet was used. Eleven newborn piglets were anesthetized and respired by a ventilator to induce stepwise hypoxia loading. The DPF showed positive linear relationship with arterial hemoglobin (Hb) oxygen saturation and sagittal sinus venous Hb oxygen saturation at 761 and 795 nm. The DPF at 835 nm also showed very slight positive linear relationship with arterial hemoglobin oxygen saturation. The DPF values obtained in this study should contribute to a better understanding of noninvasive measurements by NIRS in neonates.

Key words

near-infrared spectroscopytime-resolved reflectance spectroscopynewborn pigletsdifferential pathlength factorhypoxiabrain

Copyright information

© The Optical Society of Japan 2003