Journal of Human Genetics

, Volume 49, Issue 9, pp 495–499

Genetic background of people in the Dominican Republic with or without obese type 2 diabetes revealed by mitochondrial DNA polymorphism

  • Atsushi Tajima
  • Kazuyuki Hamaguchi
  • Hideo Terao
  • Ayako Oribe
  • Victor M. Perrotta
  • Carlos Amoros Baez
  • Jose R. Arias
  • Hironobu Yoshimatsu
  • Toshiie Sakata
  • Satoshi Horai
Original Article

DOI: 10.1007/s10038-004-0179-7

Cite this article as:
Tajima, A., Hamaguchi, K., Terao, H. et al. J Hum Genet (2004) 49: 495. doi:10.1007/s10038-004-0179-7

Abstract

People in the Dominican Republic are considered to be genetically heterogeneous owing to the post-Colombian admixture of Native American, African, and European populations. To characterize their genetic background, nucleotide sequences of the D-loop region of human mitochondrial DNA (mtDNA) were examined in 33 healthy women and 50 gender-matched patients with obese type 2 diabetes (OD) from the Dominican Republic. Phylogenetic analysis of 198 mtDNA lineages including Native Americans, Africans, and Europeans enabled us to assess relative genetic contributions of the three ancestral fractions to the two groups in the Dominican Republic. In the OD group, the majority (64.0%) of the mtDNA lineages were from African ancestry, whereas the Native American fraction was predominant (51.5%) in the healthy group, with both showing smallest amounts (14.0% and 9.1%, respectively) of European contribution. This difference in maternal genetic background between the two groups was similarly demonstrated by phylogenetic analysis at the population level based on net nucleotide diversities between populations. These findings may imply ethnic-specific predisposition to OD, a possible association of an unidentified factor from African ancestry with OD in the Dominican Republic population.

Keywords

Mitochondrial DNAD-loop regionSequence polymorphismDominican RepublicPopulation structure

Copyright information

© The Japan Society of Human Genetics and Springer-Verlag 2004

Authors and Affiliations

  • Atsushi Tajima
    • 1
  • Kazuyuki Hamaguchi
    • 2
  • Hideo Terao
    • 3
  • Ayako Oribe
    • 2
  • Victor M. Perrotta
    • 4
  • Carlos Amoros Baez
    • 4
  • Jose R. Arias
    • 5
  • Hironobu Yoshimatsu
    • 2
  • Toshiie Sakata
    • 6
  • Satoshi Horai
    • 1
  1. 1.Department of Biosystems ScienceThe Graduate University for Advanced Studies (Sokendai)Kanagawa 240-0193Japan
  2. 2.Department of Internal Medicine I, Faculty of MedicineOita UniversityOitaJapan
  3. 3.Department of Health Science CenterOita UniversityOitaJapan
  4. 4.Instituto Nacional de DiabetesEndocrinología y Nutrición (INDEN)Santo DomingoDominican Republic
  5. 5.Centro de GastroenterologiaSanto DomingoDominican Republic
  6. 6.Graduate School of Health and Nutritional SciencesNakamura Gakuen UniversityFukuokaJapan