Pediatric and Developmental Pathology

, Volume 2, Issue 1, pp 50–57

Huge Fetal Sacrococcygeal Teratoma with a Completely Formed Eye and Intratumoral DNA Ploidy Heterogeneity

Authors

  • Consolato  Sergi
    • Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220/221, D-69120 Heidelberg, Germany
  • Volker  Ehemann
    • Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220/221, D-69120 Heidelberg, Germany
  • Bernhard  Beedgen
    • Departments of Pediatrics and Neonatology, University of Heidelberg, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany
  • Otwin  Linderkamp
    • Departments of Pediatrics and Neonatology, University of Heidelberg, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany
  • Herwart F.  Otto
    • Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220/221, D-69120 Heidelberg, Germany

DOI: 10.1007/s100249900089

Cite this article as:
Sergi, C., Ehemann, V., Beedgen, B. et al. Pediatr. Dev. Pathol. (1999) 2: 50. doi:10.1007/s100249900089

ABSTRACT

Preterm infants and newborns with sacrococcygeal teratomas are at high risk for prenatal and perinatal complications. The prognosis depends on size and histology of the tumor, degree of prematurity, associated malformations, route of delivery, and prompt and complete surgical removal. Virtually any tissue can be present in a sacrococcygeal teratoma, but to date, ocular lens has been documented only as lentinoids (lens-like cells), whereas flow-cytometric data have been variably interpreted. We describe a case of a sacrococcygeal teratoma in an infant of 29 weeks gestational age that is remarkable for the weight (4500 g), the presence of a completely formed eye, and intratumoral DNA ploidy heterogeneity.

Key words: sacrococcygeal teratoma, germ cell tumor, yolk sac tumor, endodermal sinus tumor, hepatoid pattern, flow cytometry, DNA ploidy, eye

Copyright information

© Springer-Verlag New York Inc. 1999