Pediatric and Developmental Pathology

, Volume 8, Issue 6, pp 718–724

Giant Cell Tumor of Soft Tissue with Pulmonary Metastases: Pathologic and Cytogenetic Study

  • Hua Guo
  • Roberto A. Garcia
  • Mary Ann Perle
  • John Amodio
  • M. Alba Greco
Article

DOI: 10.1007/s10024-005-0014-y

Cite this article as:
Guo, H., Garcia, R.A., Perle, M.A. et al. Pediatr Dev Pathol (2005) 8: 718. doi:10.1007/s10024-005-0014-y

Abstract

Giant cell tumor of soft tissue (GCTST) has gained general acceptance as an uncommon but distinct primary soft tissue tumor since it was first described in 1972. GCTST is predominantly seen in adults and typically shows uniformly dispersed osteoclast-like giant cells admixed with oval to polygonal mononuclear cells. It usually follows a benign clinical course, although the malignant variant has been described in cases in which the mononuclear cells demonstrate obvious dysplastic features. It is still not clear whether the two variants belong to the spectrum of the same tumor. No cytogenetic chromosomal abnormalities have been reported in the literature of GCTST. Interestingly, the osseous counterpart of giant cell tumor, which shares similar histologic features, quite often displays a telomeric association at the cytogenetic level, a finding that has never been reported in GCTST. We report the case of a 12-year-old girl with GCTST of the right leg that metastasized to the lung. Cytogenetic studies from the primary tumor showed the phenomenon of telomeric association involving multiple chromosomes.

Keywords

children cytogenetics giant cell tumor soft tissue telomeric association 

Copyright information

© Society for Pediatric Pathology 2005

Authors and Affiliations

  • Hua Guo
    • 1
  • Roberto A. Garcia
    • 2
  • Mary Ann Perle
    • 3
  • John Amodio
    • 4
  • M. Alba Greco
    • 1
  1. 1.Department of Pathology, Division of Pediatric PathologyNew York University School of MedicineNew YorkUSA
  2. 2.Department of Pathology, Division of Surgical PathologyBellevue Hospital, New York University School of MedicineNew YorkUSA
  3. 3.Department of Pathology, Division of CytogeneticsBellevue Hospital, New York University School ofMedicineNew YorkUSA
  4. 4.Department of RadiologyNew York University School of MedicineNew YorkUSA

Personalised recommendations