Pediatric and Developmental Pathology

, Volume 8, Issue 2, pp 218–223

Renal Metanephric Adenoma With Previously Unreported Cytogenetic Abnormalities: Case Report and Review of the Literature

  • Dinesh Rakheja
  • Fangru Lian
  • Gail E. Tomlinson
  • David H. Ewalt
  • Roger A. Schultz
  • Linda R. Margraf
Article

DOI: 10.1007/s10024-004-7081-3

Cite this article as:
Rakheja, D., Lian, F., Tomlinson, G.E. et al. Pediatr Dev Pathol (2005) 8: 218. doi:10.1007/s10024-004-7081-3

Abstract

We report a case of a renal metanephric adenoma in a 10-year-old boy, in which cytogenetic analysis showed a balanced translocation, t(9;15)(p24;q24) and a balanced paracentric inversion of chromosome 12, inv(12)(q13q15). Immunohistochemically, the tumor showed diffuse reactivity for cytokeratin AE1/AE3, CAM5.2, CD57, and WT1; patchy reactivity for CD56; and focal reactivity for cytokeratin 7, epithelial membrane antigen, and CD10. Tumor cells were entirely nonreactive for α-methyl acyl coenzyme A racemase. Published cytogenetic data for metanephric adenomas are limited, and this is the first report of these cytogenetic abnormalities. The involvement of the chromosome region 9p24 is particularly interesting because of the recent identification of a tumor suppressor gene, KANK (kidney ankyrin repeat-containing protein), at this locus.

Keywords

metanephric adenomacytogeneticsWilms tumorpapillary renal cell carcinoma

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Dinesh Rakheja
    • 1
    • 4
  • Fangru Lian
    • 5
  • Gail E. Tomlinson
    • 2
    • 4
  • David H. Ewalt
    • 3
    • 4
  • Roger A. Schultz
    • 5
  • Linda R. Margraf
    • 1
    • 4
  1. 1.Department of PathologyChildren’s Medical Center of DallasDallasUSA
  2. 2.Department of PediatricsChildren’s Medical Center of DallasDallasUSA
  3. 3.Department of UrologyChildren’s Medical Center of DallasDallasUSA
  4. 4.University of Texas Southwestern Medical CenterDallasUSA
  5. 5.Department of PathologyUniversity of Texas Southwestern Medical CenterDallasUSA