Pediatric and Developmental Pathology

, Volume 5, Issue 6, pp 587–591

Heterotopic Nephrogenic Rests in the Colon and Multiple Congenital Anomalies: Possibly Related Association

  • Dhanpat Jain
  • Maritza Martel
  • Miguel Reyes-Múgica
  • Vinita Parkash

DOI: 10.1007/s10024-002-0055-4

Cite this article as:
Jain, D., Martel, M., Reyes-Múgica, M. et al. Pediatr. Dev. Pathol. (2002) 5: 587. doi:10.1007/s10024-002-0055-4

Heterotopic renal tissue (HRT) in the wall of the colon is a very rare occurrence, with only five cases published. Our patient is only the second patient reported to have this abnormality in the absence of sirenomelia. We describe colonic HRT in a child, associated with multiple congenital anomalies. The congenital abnormalities were of the VACTERL type, accompanied by valvular cardiac anomalies that were clinically diagnosed as Shone syndrome. The HRT was not apparent clinically or grossly. Microscopically, multifocal islands of renal tissue consisting of glomeruli, cystically dilated tubules, and blastema were seen in all layers of the bowel, and simulated "cystic partially differentiated nephroblastoma." Our case provides further support to the belief that VACTERL association and sirenomelia represent related entities.

Copyright information

© 2002 Society for Pediatric Patho logy

Authors and Affiliations

  • Dhanpat Jain
    • 1
  • Maritza Martel
    • 1
  • Miguel Reyes-Múgica
    • 1
  • Vinita Parkash
    • 1
  1. 1.Department of Pathology, Yale University School of Medicine, P.O. Box 208070, New Haven, CT 06520-8070, USAUS

Personalised recommendations