Artificial Life and Robotics

, Volume 14, Issue 1, pp 12–15

Gene subset selection using an iterative approach based on genetic algorithms

Original Article

DOI: 10.1007/s10015-009-0711-0

Cite this article as:
Mohamad, M.S., Omatu, S., Deris, S. et al. Artif Life Robotics (2009) 14: 12. doi:10.1007/s10015-009-0711-0


Microarray data are expected to be useful for cancer classification. However, the process of gene selection for the classification contains a major problem due to properties of the data such as the small number of samples compared with the huge number of genes (higher-dimensional data), irrelevant genes, and noisy data. Hence, this article aims to select a near-optimal (small) subset of informative genes that is most relevant for the cancer classification. To achieve this aim, an iterative approach based on genetic algorithms has been proposed. Experimental results show that the performance of the proposed approach is superior to other previous related work, as well as to four methods tried in this work. In addition, a list of informative genes in the best gene subsets is also presented for biological usage.

Key words

Gene selectionGenetic algorithmIterative approachMicroarray data

Copyright information

© International Symposium on Artificial Life and Robotics (ISAROB). 2009

Authors and Affiliations

  1. 1.Department of Computer Science and Intelligent Systems, Graduate School of EngineeringOsaka Prefecture UniversitySakai, OsakaJapan
  2. 2.Department of Software Engineering, Faculty of Computer Science and Information SystemsUniversiti Teknologi MalaysiaSkudai, JohoreMalaysia