Case Report

Brain Tumor Pathology

, Volume 29, Issue 1, pp 47-53

First online:

Lymphomatosis cerebri: clinical characteristics, neuroimaging, and pathological findings

  • Ryuhei KitaiAffiliated withDepartment of Neurosurgery, Faculty of Medical Sciences, University of Fukui Email author 
  • , Norichika HashimotoAffiliated withDepartment of Neurosurgery, Faculty of Medical Sciences, University of Fukui
  • , Kouji YamateAffiliated withDepartment of Neurology, Faculty of Medical Sciences, University of Fukui
  • , Masamichi IkawaAffiliated withDepartment of Neurology, Faculty of Medical Sciences, University of Fukui
  • , Makoto YonedaAffiliated withDepartment of Neurology, Faculty of Medical Sciences, University of Fukui
  • , Tsuyoshi NakajimaAffiliated withDepartment of Neurosurgery, Fukui Social Insurance Hospital
  • , Hidetaka ArishimaAffiliated withDepartment of Neurosurgery, Faculty of Medical Sciences, University of Fukui
  • , Hiroaki TakeuchiAffiliated withDepartment of Neurosurgery, Faculty of Medical Sciences, University of Fukui
  • , Kazufumi SatoAffiliated withDepartment of Neurosurgery, Faculty of Medical Sciences, University of Fukui
    • , Ken-Ichiro KikutaAffiliated withDepartment of Neurosurgery, Faculty of Medical Sciences, University of Fukui

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Abstract

Lymphomatosis cerebri is a rare variant of primary central nervous system lymphoma. We present a case involving a 56-year-old immunocompetent woman who complained of rapid deterioration of her higher brain function over a 4-month period. Magnetic resonance imaging showed extensive white-matter lesions. During brain biopsy, a diffusely infiltrating lymphoma with distinctive immunohistochemical features was detected. Awareness of this unique presentation and early tissue diagnosis provide the best hope for instituting appropriate treatments.

Keywords

PCNSL Lymphomatosis cerebri Infiltration