Brain Tumor Pathology

, 28:203

New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status

  • Ichiyo Shibahara
  • Yukihiko Sonoda
  • Masayuki Kanamori
  • Ryuta Saito
  • Toshihiro Kumabe
  • Teiji Tominaga
Review Article

DOI: 10.1007/s10014-011-0050-4

Cite this article as:
Shibahara, I., Sonoda, Y., Kanamori, M. et al. Brain Tumor Pathol (2011) 28: 203. doi:10.1007/s10014-011-0050-4

Abstract

In glioma, mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes have been receiving attention. IDH1/2 mutations are frequently found in grade II and III gliomas. These genetic alterations occur very early in gliomagenesis and strongly predict favorable outcome in patients with high-grade gliomas. Despite the evolution of studies on this topic, the underlying mechanism of the IDH1/2 mutations remains unknown. Here, we briefly review the current knowledge of IDH1/2 and discuss molecular diagnostics based on IDH1/2 gene status.

Keywords

IDH1 Glioblastoma Astrocytoma Oligodendroglioma Pilocytic astrocytoma 

Copyright information

© The Japan Society of Brain Tumor Pathology 2011

Authors and Affiliations

  • Ichiyo Shibahara
    • 1
  • Yukihiko Sonoda
    • 1
  • Masayuki Kanamori
    • 1
  • Ryuta Saito
    • 1
  • Toshihiro Kumabe
    • 1
  • Teiji Tominaga
    • 1
  1. 1.Department of NeurosurgeryTohoku University School of MedicineSendaiJapan

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