Brain Tumor Pathology

, Volume 28, Issue 2, pp 167–174

Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports

  • Shin-ichiro Osawa
  • Toshihiro Kumabe
  • Ryuta Saito
  • Yukihiko Sonoda
  • Hidetaka Niizuma
  • Mika Watanabe
  • Teiji Tominaga
Case Report

DOI: 10.1007/s10014-010-0014-0

Cite this article as:
Osawa, S., Kumabe, T., Saito, R. et al. Brain Tumor Pathol (2011) 28: 167. doi:10.1007/s10014-010-0014-0
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Abstract

Three pediatric patients with infratentorial metastatic non-epithelial malignant brain tumors were successfully treated by radical surgical resection followed by aggressive radiochemotherapy. One patient with neuroblastoma and two with rhabdomyosarcoma were successfully treated by first line multimodal treatments, but developed infratentorial metastasis after several months of remission. All patients revealed intracranial metastases manifesting as rapidly progressing neurological symptoms caused by mass effect in the posterior fossa. Radical surgical resection was performed without morbidity. The patients were then treated by adjuvant radiochemotherapy with or without autologous peripheral blood stem cell transplantation, resulting in complete remission. Two patients developed extracranial recurrences 4 months after the treatments for intracranial metastases. One patient was treated by second high-dose chemotherapy with allogeneic cord blood transplantation, again resulting in complete remission. Another patient was treated by second chemotherapy and maintaining stable disease. The other patient maintained complete remission. All three patients were alive without neurological deficit for 8, 11, and 12 months after diagnosis of brain metastasis. Patients with infratentorial brain metastases of highly malignant pediatric non-epithelial tumors are in a severe clinical state, but still can have longer and useful lives with aggressive multimodal treatments combined with radical surgical resection.

Keywords

Brain metastasis Neuroblastoma Pediatric cancer Rhabdomyosarcoma Surgery 

Copyright information

© The Japan Society of Brain Tumor Pathology 2010

Authors and Affiliations

  • Shin-ichiro Osawa
    • 1
  • Toshihiro Kumabe
    • 1
  • Ryuta Saito
    • 1
  • Yukihiko Sonoda
    • 1
  • Hidetaka Niizuma
    • 2
  • Mika Watanabe
    • 3
  • Teiji Tominaga
    • 1
  1. 1.Department of NeurosurgeryTohoku University Graduate School of MedicineSendaiJapan
  2. 2.Department of PediatricsTohoku University Graduate School of MedicineSendaiJapan
  3. 3.Department of PathologyTohoku University HospitalSendaiJapan

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