Brain Tumor Pathology

, Volume 28, Issue 1, pp 1–12

Glioma-initiating cells and molecular pathology: implications for therapy

Authors

  • Atsushi Natsume
    • Department of NeurosurgeryNagoya University School of Medicine
  • Sayano Kinjo
    • Department of NeurosurgeryNagoya University School of Medicine
  • Kanako Yuki
    • Department of NeurosurgeryNagoya University School of Medicine
  • Takenori Kato
    • Department of NeurosurgeryNagoya University School of Medicine
  • Masasuke Ohno
    • Department of NeurosurgeryNagoya University School of Medicine
  • Kazuya Motomura
    • Department of NeurosurgeryNagoya University School of Medicine
  • Kenichiro Iwami
    • Department of NeurosurgeryNagoya University School of Medicine
    • Department of NeurosurgeryNagoya University School of Medicine
Review Article

DOI: 10.1007/s10014-010-0011-3

Cite this article as:
Natsume, A., Kinjo, S., Yuki, K. et al. Brain Tumor Pathol (2011) 28: 1. doi:10.1007/s10014-010-0011-3

Abstract

There is now compelling evidence that gliomas harbor a small population of cells, termed glioma-initiating cells (GICs), characterized by their ability to undergo self-renewal and initiate tumorigenesis. The development of therapeutic strategies targeted toward GIC signaling may improve the treatment of malignant gliomas. The characterization of GICs provides a clue to elucidating histological heterogeneity and treatment failure. The role of the stem cell marker CD133 in the initiation and progression of brain tumors is still uncertain. Here, we review some of the signaling mechanisms involved in GIC biology, such as phosphatase and tensin homolog (PTEN), sonic hedgehog, Notch, and WNT signaling pathways, maternal embryonic leucine-zipper kinase (MELK), BMI1, and Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling. In addition, we discuss the role of microRNAs in GICs by focusing on microRNA-21 regulation by type I interferon.

Keywords

Glioma-initiating cells CD133 Molecular pathways STAT3 MicroRNAs

Copyright information

© The Japan Society of Brain Tumor Pathology 2011