Efficient electrocatalytic oxidation and selective determination of isoniazid by Fe(tmphen)32+-exchanged Nafion®-modified electrode
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- Azad, U.P. & Ganesan, V. J Solid State Electrochem (2012) 16: 2907. doi:10.1007/s10008-012-1724-5
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Cyclic voltammetry and electrochemical impedance studies of Fe(tmphen)32+ (where tmphen = 3,4,7,8-tetramethyl-1,10-phenanthroline)-immobilized Nafion®-modified glassy carbon electrode (GC/Nf/Fe(tmphen)32+) are carried out in 0.1 M Na2SO4 solution. Nafion–Fe(tmphen)32+ complex exhibits efficient electrocatalytic oxidation of isoniazid. The linear double reciprocal plot of current and concentration of isoniazid shows a Michaelis–Menten-type catalytic process. The catalytic oxidation currents are proportional to the concentration of isoniazid and show a wide linear calibration range for the quantitative determination of isoniazid. Detection limit and sensitivity are found to be 13 μM and 2.5 μA mM−1, respectively.