Keratocystic odontogenic tumour (KCOT)—a cyst to a tumour
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The World Health Organization (WHO) has reclassified ‘odontogenic keratocyst’ (OKC) to ‘keratocystic odontogenic tumour’ (KCOT) in 2005. Currently, this tumour is classified as a benign neoplasm of odontogenic origin and not as a cyst. This article reviews and discusses history, classification scheme, aetiology and pathogenesis, molecular and genetic basis, incidence, epidemiology and site, clinical features, imaging, histopathology, immunohistochemistry, treatment options, prognosis, recurrence and malignant transformation of KCOT, with emphasis on understanding the basis of reclassification as ‘keratocystic odontogenic tumour’.
A systematic search and review of the literature was carried out in the online database of the United States National Library of Medicine to identify eligible titles for the study.
Current evidence suggests that the scientific community still continues to use the term ‘odontogenic keratocyst’ more favourably than ‘keratocystic odontogenic tumour’.
The online database search indicates that the scientific community still continues to use the term ‘odontogenic keratocyst’ more favourably than ‘keratocystic odontogenic tumour’. At this juncture, where the terminology has changed from a cyst to a tumour, a thorough review of literature on KCOT is presented.
- Keratocystic odontogenic tumour (KCOT)—a cyst to a tumour
Oral and Maxillofacial Surgery
Volume 16, Issue 2 , pp 163-170
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Keratocystic odontogenic tumour, KCOT
- Odontogenic keratocyst, OKC
- Odontogenic cysts
- Odontogenic tumours
- Industry Sectors
- Author Affiliations
- 1. Smile Mechanics—Centre for Maxillofacial Surgery & Dental Implantology, H-3/2, B.D.A. Colony, Nayapura, Lalghati, Airport Road, Bhopal, Madhya Pradesh, 462032, India
- 2. Department of Oral Medicine and Radiology, Peoples Dental Academy, Bhanpur, Bhopal, Madhya Pradesh, India
- 3. Department of Oral and Maxillofacial Surgery, University of California, San Francisco, 521 Parnassus Avenue, Room C-522, San Francisco, CA, 94143-044, USA