Original Paper

Journal of Molecular Modeling

, Volume 18, Issue 2, pp 607-609

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

An information-carrying and knowledge-producing molecular machine. A Monte-Carlo simulation

  • Christoph KuhnAffiliated withBiomedical Optics Research Laboratory, Clinic of Neonatology, University Hospital Zürich Email author 


The concept called Knowledge is a measure of the quality of genetically transferred information. Its usefulness is demonstrated quantitatively in a Monte-Carlo simulation on critical steps in a origin of life model. The model describes the origin of a bio-like genetic apparatus by a long sequence of physical-chemical steps: it starts with the presence of a self-replicating oligomer and a specifically structured environment in time and space that allow for the formation of aggregates such as assembler-hairpins-devices and, at a later stage, an assembler-hairpins-enzyme device—a first translation machine.


Assembler-hairpins-enzyme device Emergence and storage of information Genetic apparatus Knowledge Monte-Carlo Origin of life Structured time-space environment