Review

Medical Molecular Morphology

, Volume 47, Issue 1, pp 1-7

First online:

Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide

  • Akira MatsunoAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical Center Email author 
  • , Mineko MurakamiAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical Center
  • , Katsumi HoyaAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical Center
  • , Shoko M. YamadaAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical Center
  • , Shinya MiyamotoAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical Center
  • , So YamadaAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical Center
  • , Jae-Hyun SonAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical Center
  • , Hajime NishidoAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical Center
  • , Fuyuaki IdeAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical Center
    • , Hiroshi NagashimaAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical Center
    • , Mutsumi SugayaAffiliated withDepartment of Rehabilitation, Teikyo University Chiba Medical Center
    • , Toshio HirohataAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical CenterDepartment of Neurosurgery, The University of Tokyo
    • , Akiko MizutaniAffiliated withDepartment of Neurosurgery, Teikyo University Chiba Medical CenterTeikyo Heisei University
    • , Hiroko OkinagaAffiliated withTeikyo Heisei University
    • , Yudo IshiiAffiliated withDepartment of Neurosurgery, Nippon Medical School
    • , Shigeyuki TaharaAffiliated withDepartment of Neurosurgery, Nippon Medical School
    • , Akira TeramotoAffiliated withDepartment of Neurosurgery, Nippon Medical School
    • , R. Yoshiyuki OsamuraAffiliated withDepartment of Pathology, International University of Health and Welfare Mita Hospital

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Abstract

There have been several reports of temozolomide (TMZ) treatment of pituitary carcinomas and atypical adenomas. O6-methyl-guanine-DNA methyltransferase is not the sole molecule determining the sensitivity to TMZ in pituitary carcinomas and atypical adenomas. The Japan Society of Hypothalamic and Pituitary Tumors study suggests that MSH6, one of mismatch repair pathway enzyme, fulfills a contributory role to the efficacy of TMZ treatment for pituitary carcinomas and atypical adenomas. The preserved MSH6 function might be essential for the responsiveness to TMZ treatment in pituitary carcinomas and atypical adenomas.

Keywords

Pituitary carcinomas and atypical adenomas Temozolomide O6-Methyl-guanine-DNA methyltransferase Mismatch repair pathway MSH6