Medical Molecular Morphology

, Volume 42, Issue 2, pp 128–131

The majority of triple-negative breast cancer may correspond to basal-like carcinoma, but triple-negative breast cancer is not identical to basal-like carcinoma

  • Naoto Kuroda
  • Masahiko Ohara
  • Kaori Inoue
  • Keiko Mizuno
  • Nokiaki Fujishima
  • Nobumasa Hamaguchi
  • Gang-Hong Lee
Original Paper

DOI: 10.1007/s00795-008-0428-5

Cite this article as:
Kuroda, N., Ohara, M., Inoue, K. et al. Med Mol Morphol (2009) 42: 128. doi:10.1007/s00795-008-0428-5

Abstract

Recently, the concept of basal-like carcinoma has been proposed. However, there are only a few reports about the relationship between triple-negative cancer and basal-like carcinoma. In this article, we report the study of the expression of basal cell markers in 11 triple-negative cancers. Eight tumors (4 metaplastic carcinomas, 2 invasive ductal carcinomas, 1 invasive papillary carcinoma, and 1 medullary carcinoma) were positive for more than three markers among cytokeratins 5, 14, and 17, and p63. Three tumors (2 invasive ductal carcinomas and 1 apocrine carcinoma) were completely negative for all markers. Among 8 tumors positive for basal markers, cytokeratins 5 and 17 were expressed in all 8 tumors, cytokeratin 14 in 6 tumors, and p63 in 7 tumors. Finally, we conclude that the majority of triple-negative cancer may correspond to basal-like carcinoma, but the two entities are not identical. The use of combination immunohistochemistry including cytokeratins 5, 14, and 17 and p63 may contribute to the detection of basal-like carcinoma.

Key words

Triple-negative cancerBasal-like carcinomaImmunohistochemistry

Copyright information

© The Japanese Society for Clinical Molecular Morphology 2009

Authors and Affiliations

  • Naoto Kuroda
    • 1
  • Masahiko Ohara
    • 1
  • Kaori Inoue
    • 1
  • Keiko Mizuno
    • 1
  • Nokiaki Fujishima
    • 2
  • Nobumasa Hamaguchi
    • 2
  • Gang-Hong Lee
    • 3
  1. 1.Department of Diagnostic PathologyKochi Red Cross HospitalKochiJapan
  2. 2.Department of SurgeryKochi Red Cross HospitalKochiJapan
  3. 3.Department of Pathology, Kochi Medical SchoolKochi UniversityKochiJapan