Medical Molecular Morphology

, Volume 40, Issue 4, pp 185–190

Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention

  • Yoichiro Matsuoka
  • Tetsuya Hamaguchi
  • Katsumi Fukamachi
  • Midori Yoshida
  • Gen Watanabe
  • Kazuyoshi Taya
  • Hiroyuki Tsuda
  • Airo Tsubura
SPECIAL REVIEW SERIES: Carcinogenesis of breast carcinoma and its development

DOI: 10.1007/s00795-007-0369-4

Cite this article as:
Matsuoka, Y., Hamaguchi, T., Fukamachi, K. et al. Med Mol Morphol (2007) 40: 185. doi:10.1007/s00795-007-0369-4

Abstract

A rat strain carrying the human c-Ha-ras proto-oncogene is highly susceptible to chemically induced mammary carcinogenesis. All the transgenic rats develop preneoplastic mammary lesions within 20 days of an injection of N-methyl-N-nitrosourea, and mammary carcinomas appear within 8 weeks of treatment with a variety of chemical carcinogens. In this review, we summarize molecular aspects of mammary carcinogenesis in transgenic rats and the potential application of this model for studies of breast cancer prevention.

Key words

Mammary carcinoma Preneoplasia Prevention ras Transgenic rat 

Copyright information

© The Japanese Society for Clinical Molecular Morphology 2007

Authors and Affiliations

  • Yoichiro Matsuoka
    • 1
  • Tetsuya Hamaguchi
    • 2
  • Katsumi Fukamachi
    • 3
  • Midori Yoshida
    • 4
  • Gen Watanabe
    • 5
  • Kazuyoshi Taya
    • 5
  • Hiroyuki Tsuda
    • 3
  • Airo Tsubura
    • 1
  1. 1.Second Department of PathologyKansai Medical UniversityOsakaJapan
  2. 2.Second Department of SurgeryMie University School of MedicineMieJapan
  3. 3.Department of Molecular ToxicologyNagoya City University Graduate School of Medical SciencesNagoyaJapan
  4. 4.Experimental Pathology Team, Research Center for Radiation ProtectionNational Institute of Radiological SciencesChibaJapan
  5. 5.Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of AgricultureTokyo University of Agriculture and TechnologyTokyoJapan