Medical Molecular Morphology

, Volume 40, Issue 3, pp 168–171

Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures

  • Naoto Kuroda
  • Shin-ichi Iwamura
  • Nokiaki Fujishima
  • Masahiko Ohara
  • Takashi Hirouchi
  • Keiko Mizuno
  • Yoshihiro Hayashi
  • Gang-Hong Lee
ORIGINAL PAPER

DOI: 10.1007/s00795-006-0349-0

Cite this article as:
Kuroda, N., Iwamura, S., Fujishima, N. et al. Med Mol Morphol (2007) 40: 168. doi:10.1007/s00795-006-0349-0

Abstract

A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and squamous cell carcinoma. Additionally, undifferentiated spindle or pleomorphic cells were seen in continuity with the carcinoma component. Undifferentiated neoplastic cells with rhabdoid features and with hyaline globule-like structures positive for PAS stain with diastase pretreatment were also observed. Immunohistochemically, cytoplasmic inclusions corresponding to rhabdoid features showed aggregates of vimentin. Ultrastructurally, hyaline globule-like structures corresponded to lysosomes. Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures.

Key words

Anaplastic carcinomaPancreasHyaline globule-like structuresUltrastructure

Copyright information

© The Japanese Society for Clinical Molecular Morphology 2007

Authors and Affiliations

  • Naoto Kuroda
    • 1
  • Shin-ichi Iwamura
    • 2
  • Nokiaki Fujishima
    • 3
  • Masahiko Ohara
    • 1
  • Takashi Hirouchi
    • 1
  • Keiko Mizuno
    • 1
  • Yoshihiro Hayashi
    • 4
  • Gang-Hong Lee
    • 4
  1. 1.Departments of Pathology and Laboratory MedicineKochi Red Cross HospitalKochi CityJapan
  2. 2.Department of Internal MedicineKochi Red Cross HospitalKochiJapan
  3. 3.Department of SurgeryKochi Red Cross HospitalKochiJapan
  4. 4.Department of Pathology, Program of Bioregulation and GeneticsKochi Medical School, Kochi UniversityKochiJapan