ORIGINAL PAPER

Medical Molecular Morphology

, Volume 40, Issue 3, pp 168-171

Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures

  • Naoto KurodaAffiliated withDepartments of Pathology and Laboratory Medicine, Kochi Red Cross Hospital Email author 
  • , Shin-ichi IwamuraAffiliated withDepartment of Internal Medicine, Kochi Red Cross Hospital
  • , Nokiaki FujishimaAffiliated withDepartment of Surgery, Kochi Red Cross Hospital
  • , Masahiko OharaAffiliated withDepartments of Pathology and Laboratory Medicine, Kochi Red Cross Hospital
  • , Takashi HirouchiAffiliated withDepartments of Pathology and Laboratory Medicine, Kochi Red Cross Hospital
  • , Keiko MizunoAffiliated withDepartments of Pathology and Laboratory Medicine, Kochi Red Cross Hospital
  • , Yoshihiro HayashiAffiliated withDepartment of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University
  • , Gang-Hong LeeAffiliated withDepartment of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University

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Abstract

A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and squamous cell carcinoma. Additionally, undifferentiated spindle or pleomorphic cells were seen in continuity with the carcinoma component. Undifferentiated neoplastic cells with rhabdoid features and with hyaline globule-like structures positive for PAS stain with diastase pretreatment were also observed. Immunohistochemically, cytoplasmic inclusions corresponding to rhabdoid features showed aggregates of vimentin. Ultrastructurally, hyaline globule-like structures corresponded to lysosomes. Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures.

Key words

Anaplastic carcinoma Pancreas Hyaline globule-like structures Ultrastructure