European Child & Adolescent Psychiatry

, Volume 21, Issue 2, pp 101–109

Low frequency oscillations of response time explain parent ratings of inattention and hyperactivity/impulsivity

  • María Ángeles Mairena
  • Adriana Di Martino
  • Cristina Domínguez-Martín
  • Lorena Gómez-Guerrero
  • Gerard Gioia
  • Eva Petkova
  • F. Xavier Castellanos
Original Contribution

DOI: 10.1007/s00787-011-0237-6

Cite this article as:
Mairena, M.Á., Martino, A.D., Domínguez-Martín, C. et al. Eur Child Adolesc Psychiatry (2012) 21: 101. doi:10.1007/s00787-011-0237-6

Abstract

Greater intra-subject variability (ISV) in response time is a heritable endophenotype of attention-deficit/hyperactivity disorder (ADHD). Spontaneous low frequency oscillations (LFO: 0.01–0.1 Hz) observed in brain functional magnetic resonance signals might account for such behavioral variability. Recently, we demonstrated that ISV in response time (RT) explained ratings of ADHD symptoms. Building on this finding, here we hypothesized that LFO in RT time series would explain these ratings, both independently and in addition to RT coefficient of variation (CV). To measure RT LFO, we applied Morlet wavelet transform to the previously collected RT data. Our community sample consisted of 98 children (including 66 boys, mean age 9.9 ± 1.4 years), who completed four computer Tasks of Executive Control. Conners’ Parent Rating Scale ratings were obtained. RT LFO of three tasks significantly explained ratings of inattention, hyperactivity and three global Conners’ subscales. In addition, RT LFO during two tasks that included an inhibitory component increased the proportions of variance explained in subscales of both inattention and hyperactivity/impulsivity, beyond the effects of RT-CV. Three specific low frequency bands (Slow-5: 0.01–0.027 Hz; Slow-4: 0.027–0.073 Hz; Slow-3: 0.073–0.20 Hz) were strongly related to the ADHD scales. We conclude that RT LFO predict dimensional ratings of ADHD symptoms both independently and in addition to RTCV. Results suggest that frequency analyses are a suitable methodology to link behavioral responses to putative underlying physiological processes.

Keywords

Attention-deficit/hyperactivity disorder Intra-subject variability Frequency analyses Rating scales 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • María Ángeles Mairena
    • 1
    • 2
  • Adriana Di Martino
    • 1
  • Cristina Domínguez-Martín
    • 3
  • Lorena Gómez-Guerrero
    • 4
  • Gerard Gioia
    • 5
  • Eva Petkova
    • 6
  • F. Xavier Castellanos
    • 1
    • 7
  1. 1.Phyllis Green and Randolph Cōwen Institute for Pediatric NeuroscienceNYU Child Study CenterNew YorkUSA
  2. 2.Hospital Sant Joan de Déu. CIBERSAMBarcelonaSpain
  3. 3.Hospital Clínico Universitario de ValladolidValladolidSpain
  4. 4.Unidad de Salud Mental Infanto JuvenilComplejo Hospitalario de OurenseCiudad OrenseSpain
  5. 5.Departments of Pediatrics and PsychiatryGeorge Washington University School of MedicineRockvilleUSA
  6. 6.Division of Biostatistics at the Department of Child and Adolescent PsychiatryNYU Langone Medical CenterNew YorkUSA
  7. 7.Nathan Kline Institute for Psychiatric ResearchOrangeburgUSA

Personalised recommendations