Clinical Oral Investigations

, Volume 18, Issue 1, pp 261–268

Oral and genital HPV genotypic concordance between sexual partners

  • Camila Maria Beder Ribeiro
  • Iracema Ferrer
  • Andreza Barkokebas Santos de Farias
  • Débora Diniz Fonseca
  • Igor Henrique Morais Silva
  • Luiz Alcino Monteiro Gueiros
  • Alessandra Tavares Carvalho
  • Stephen Ross Porter
  • Jair Carneiro Leao
Original Article

DOI: 10.1007/s00784-013-0959-6

Cite this article as:
Beder Ribeiro, C.M., Ferrer, I., Santos de Farias, A.B. et al. Clin Oral Invest (2014) 18: 261. doi:10.1007/s00784-013-0959-6

Abstract

Objectives

The aim of this study was to verify human papillomavirus (HPV) transmission and genotype concordance among heterosexual couples.

Materials and methods

Thirty-one married couples were evaluated. All male subjects presented with clinically diagnosed HPV-related malignant or potentially malignant lesions and underwent peniscopy and penile swab. Their female counterparts underwent swabs of the uterine cervix and oral mucosa. HPV-DNA detection was performed by polymerase chain reaction and restriction fragment length polymorphism.

Results

HPV-DNA was detected in the penis, vagina/cervix, and oral cavity of 16 couples (51.61 %). Of these, HPV-DNA concordance was observed in 14 couples (87.5 %). HPV-DNA was amplified in penile and oral sites of 14 couples. Of these, 13 couples reported fellatio (92.85 %), most of them (10 couples, 76.9 %) without condom use. HPV-DNA concordance was observed in 7/10 of these couples (70 %). The three couples (100 %) who reported use of condom during fellatio were HPV-DNA discordant (p = 0.025).

Conclusions

Lifetime number of female sexual partners and detection of HPV-DNA in the penile mucosa are surrogate markers of exposure to HPV during marriage. Consistent use of condoms may reduce the risk of HPV transmission.

Clinical relevance

Oral acquisition of HPV from oro-genital contact is influenced by lack of condom use and previous sexual behavior of the male partner. In addition, oral transmission of the virus due to fellatio is as common as genital transmission.

Keywords

Sexually transmitted diseasesViral transmissionSexual partnersDNA probesHPVPolymerase chain reactionPolymorphism restriction fragment length

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Camila Maria Beder Ribeiro
    • 1
  • Iracema Ferrer
    • 1
  • Andreza Barkokebas Santos de Farias
    • 1
    • 2
  • Débora Diniz Fonseca
    • 1
  • Igor Henrique Morais Silva
    • 1
  • Luiz Alcino Monteiro Gueiros
    • 1
  • Alessandra Tavares Carvalho
    • 1
  • Stephen Ross Porter
    • 3
  • Jair Carneiro Leao
    • 1
    • 3
    • 4
  1. 1.Departamento de Clinica e Odontologia PreventivaUniversidade Federal de PernambucoRecifeBrazil
  2. 2.Instituto de Medicina Integral, Prof. Fernando Figueira (IMIP)RecifeBrazil
  3. 3.Oral Medicine, Division of Maxillofacial Diagnostic, Surgical and Medical SciencesEastman Dental InstituteLondonUK
  4. 4.Oral Medicine UnitUniversidade Federal de PernambucoRecifeBrazil