Clinical Oral Investigations

, Volume 15, Issue 6, pp 953–958

Periodontal treatment decreases plasma oxidized LDL level and oxidative stress

Authors

  • Naofumi Tamaki
    • Department of Preventive Dentistry, Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences
    • Department of Preventive Dentistry, Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences
  • Daisuke Ekuni
    • Department of Preventive Dentistry, Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences
  • Reiko Yamanaka
    • Department of Preventive Dentistry, Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences
  • Manabu Morita
    • Department of Preventive Dentistry, Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences
Original Article

DOI: 10.1007/s00784-010-0458-y

Cite this article as:
Tamaki, N., Tomofuji, T., Ekuni, D. et al. Clin Oral Invest (2011) 15: 953. doi:10.1007/s00784-010-0458-y

Abstract

Periodontitis induces excessive production of reactive oxygen species in periodontal lesions. This may impair circulating pro-oxidant/anti-oxidant balance and induce the oxidation of low-density lipoprotein (LDL) in blood. The purpose of this study was to monitor circulating oxidized LDL and oxidative stress in subjects with chronic periodontitis following non-surgical periodontal treatment. Plasma levels of oxidized LDL and oxidative stress in 22 otherwise healthy non-smokers with chronic periodontitis (mean age 44.0 years) were measured at baseline and at 1 and 2 months after non-surgical periodontal treatment. At baseline, chronic periodontitis patients had higher plasma levels of oxidized LDL and oxidative stress than healthy subjects (p < 0.001). Periodontal treatment was associated with a significant reduction in plasma levels of oxidized LDL (oxLDL)(p < 0.001) and oxidative stress (p < 0.001). At 2 months after periodontal treatment, the degree of change in the oxLDL was positively correlated with that in the oxidative stress (r = 0.593, p = 0.004). These observations indicate that periodontitis patients showed higher levels of circulating oxLDL and oxidative stress than healthy subjects. In addition, improved oral hygiene and non-surgical periodontal treatment were effective in decreasing oxLDL, which was positively associated with a reduction in circulating oxidative stress.

Keywords

PeriodontitisOxidative stressOxidized LDLNon-surgical therapy

Copyright information

© Springer-Verlag 2010