JBIC Journal of Biological Inorganic Chemistry

, Volume 19, Issue 2, pp 259–270

Molecular imaging of EGFR/HER2 cancer biomarkers by protein MRI contrast agents

  • Jingjuan Qiao
  • Shenghui Xue
  • Fan Pu
  • Natalie White
  • Jie Jiang
  • Zhi-Ren Liu
  • Jenny J. Yang
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DOI: 10.1007/s00775-013-1076-3

Cite this article as:
Qiao, J., Xue, S., Pu, F. et al. J Biol Inorg Chem (2014) 19: 259. doi:10.1007/s00775-013-1076-3
Part of the following topical collections:
  1. Topical Issue on Metal-Based MRI Contrast Agents

Abstract

Epidermal growth factor receptor (EGFR) and HER2 are major prognosis biomarkers and drug targets overexpressed in various types of cancer cells. There is a pressing need to develop MRI contrast agents capable of enhancing the contrast between normal tissues and tumors with high relaxivity, capable of targeting tumors, and with high intratumoral distribution and minimal toxicity. In this review, we first discuss EGFR signaling and its role in tumor progression as a major drug target. We then report our progress in the development of protein contrast agents with significant improvement of both r1 and r2 relaxivities, pharmacokinetics, in vivo retention time, and in vivo dose efficiency. Finally, we report our effort in the development of EGFR-targeted protein contrast agents with the capability to cross the endothelial boundary and with good tissue distribution across the entire tumor mass. The noninvasive capability of MRI to visualize spatially and temporally the intratumoral distribution as well as quantify the levels of EGFR and HER2 would greatly improve our ability to track changes of the biomarkers during tumor progression, monitor treatment efficacy, aid in patient selection, and further develop novel targeted therapies for clinical application.

Keywords

MRIContrast agentMolecular imagingProtein engineeringEpidermal growth factor receptor/HER2

Copyright information

© SBIC 2013

Authors and Affiliations

  • Jingjuan Qiao
    • 1
  • Shenghui Xue
    • 1
    • 2
  • Fan Pu
    • 1
  • Natalie White
    • 1
  • Jie Jiang
    • 1
  • Zhi-Ren Liu
    • 2
    • 3
  • Jenny J. Yang
    • 1
    • 3
  1. 1.Department of ChemistryGeorgia State UniversityAtlantaUSA
  2. 2.Department of BiologyGeorgia State UniversityAtlantaUSA
  3. 3.Center for Diagnostics and TherapeuticsGeorgia State UniversityAtlantaUSA