A possible molecular link between the toxicological effects of arsenic, selenium and methylmercury: methylmercury(II) seleno bis(S-glutathionyl) arsenic(III)

  • Malgorzata Korbas
  • Andrew J. Percy
  • Jürgen Gailer
  • Graham Neil George
Original Paper

DOI: 10.1007/s00775-007-0336-5

Cite this article as:
Korbas, M., Percy, A.J., Gailer, J. et al. J Biol Inorg Chem (2008) 13: 461. doi:10.1007/s00775-007-0336-5

Abstract

Using a combination of As and Se K-edge and Hg LIII-edge X-ray absorption spectroscopy, 77Se nuclear magnetic resonance spectroscopy, electrospray ionization mass spectrometry and molecular modeling, we have structurally characterized the novel species methylmercury(II) seleno bis(S-glutathionyl) arsenic(III). This species is formed in aqueous solution from CH3HgOH and the seleno bis(S-glutathionyl) arsinium ion and constitutes an important first step towards characterizing the observed toxicologically relevant interaction between arsenite, selenite and methylmercury which has been previously reported in mammals.

Keywords

Toxicology X-ray absorption spectroscopy Molecular modeling Arsenic Selenium 

Copyright information

© SBIC 2007

Authors and Affiliations

  • Malgorzata Korbas
    • 1
  • Andrew J. Percy
    • 2
  • Jürgen Gailer
    • 2
  • Graham Neil George
    • 1
  1. 1.Department of Geological SciencesUniversity of SaskatchewanSaskatoonCanada
  2. 2.Department of ChemistryUniversity of CalgaryCalgaryCanada

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