Journal of Bone and Mineral Metabolism

, Volume 20, Issue 3, pp 164–169

Association of gene polymorphisms and bone density in Japanese girls

  • Kiyoe Katsumata
  • Kyoko Nishizawa
  • Atsushi Unno
  • Yuko Fujita
  • Akifumi Tokita

DOI: 10.1007/s007740200023

Cite this article as:
Katsumata, K., Nishizawa, K., Unno, A. et al. J Bone Miner Metab (2002) 20: 164. doi:10.1007/s007740200023

Abstract.

Although some studies have reported a relationship between several candidate polymorphic genes and bone mineral density (BMD), little is known concerning the genetic factors influencing BMD in children. This study examined this relationship in healthy Japanese girls (n = 125; age, 13.4 ± 0.89 years; range, 12–15 years). We investigated allelic variants of the vitamin D receptor (VDR) gene, the estrogen receptor (ER) gene, the parathyroid hormone (PTH) gene, the Ca-sensing receptor (CaSR) gene, and the β3-adrenergic receptor (β3-AR) gene. The genotype of the VDR gene (Fok I) correlated with lumbar spine, and femoral neck BMD. The PTH polymorphisms (BstB I, Dra II) were also associated with lumbar spine BMD. No relationship was found between genotypes of the ER gene, CaSR gene, or β3-AR gene and BMD. The age, height, weight, and body mass index did not differ significantly among girls with different VDR and PTH genotypes. These results suggest that the Fok I polymorphism of the VDR gene and the Dra II polymorphism of the PTH gene are risk factors for low bone density in Japanese girls.

Key words children bone mineral density polymorphism vitamin D receptor parathyroid hormone 

Copyright information

© Springer-Verlag Tokyo 2002

Authors and Affiliations

  • Kiyoe Katsumata
    • 1
  • Kyoko Nishizawa
    • 1
  • Atsushi Unno
    • 1
  • Yuko Fujita
    • 1
  • Akifumi Tokita
    • 1
  1. 1.Department of Pediatrics, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanJP

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