Journal of Bone and Mineral Metabolism

, Volume 31, Issue 6, pp 613–617

A report from Fukushima: an assessment of bone health in an area affected by the Fukushima nuclear plant incident

  • Takeaki Ishii
  • Kazuo Ito
  • Shigeaki Kato
  • Masaharu Tsubokura
  • Sae Ochi
  • Yukihide Iwamoto
  • Yasutoshi Saito
Report

DOI: 10.1007/s00774-013-0482-5

Cite this article as:
Ishii, T., Ito, K., Kato, S. et al. J Bone Miner Metab (2013) 31: 613. doi:10.1007/s00774-013-0482-5

Abstract

Bone health was assessed for inhabitants of an area affected by the Fukushima nuclear plant incident. Osteoporotic patients, who had been treated with active vitamin D3 and/or bisphosphonate at Soma Central Hospital before the Fukushima incident, were enrolled. Changes in bone turnover markers and bone mineral density were retrospectively analyzed. Serum levels of a bone resorption marker, serum type I collagen cross-linked N-telopeptide were decreased in all the treated groups, whereas those of a bone formation marker, bone-specific alkaline phosphatase, were increased. Accordingly, bone mineral density, estimated by dual-energy X-ray absorptiometry, was increased in the lumbar spine of all groups, but bone mass increase in the proximal femur was detected only in the group treated with the two agents in combination. From the degree of these parameter changes, the antiosteoporotic treatments looked effective and were equivalent to the expected potency of past observations. At this stage, the present study implies that the Fukushima nuclear incident did not bring an acute risk to bone health in the affected areas.

Keywords

Radiation exposure Bone metabolic marker Bone mineral density Osteoporosis Disaster 

Copyright information

© The Japanese Society for Bone and Mineral Research and Springer Japan 2013

Authors and Affiliations

  • Takeaki Ishii
    • 1
    • 2
  • Kazuo Ito
    • 3
  • Shigeaki Kato
    • 4
  • Masaharu Tsubokura
    • 4
    • 6
  • Sae Ochi
    • 7
    • 8
  • Yukihide Iwamoto
    • 2
  • Yasutoshi Saito
    • 5
  1. 1.Department of Orthopaedic SurgerySoma Central HospitalSomaJapan
  2. 2.Department of Orthopaedic Surgery, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  3. 3.Department of Orthopaedic SurgeryJR Sendai HospitalSendaiJapan
  4. 4.Department of Radiation ProtectionSoma Central HospitalSomaJapan
  5. 5.Department of Internal MedicineSoma Central HospitalSomaJapan
  6. 6.Division of Social Communication System for Advanced Clinical Research, The Institute of Medical ScienceUniversity of TokyoTokyoJapan
  7. 7.MRC-HPA Centre for Environment and HealthImperial College LondonLondonUK
  8. 8.Seisa UniversityYokohamaJapan

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