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Reduced serum osteocalcin concentrations are associated with type 2 diabetes mellitus and the metabolic syndrome components in postmenopausal women: the crosstalk between bone and energy metabolism

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Abstract

Although it has been shown that osteocalcin functions as a hormone in the regulation of glucose metabolism and fat mass, no population-based study to date has addressed serum osteocalcin levels in relation to energy metabolism concurrent with bone metabolism in postmenopausal women. In a population-based study, cardiovascular risk factors, high-sensitivity C-reactive protein (hs-CRP), osteoprotegerin, receptor activator of nuclear factor-κB ligand, osteocalcin, CrossLaps, alkaline phosphatase, and bone mineral density (BMD) at the lumbar spine (L2–L4) and the proximal femur were measured in 382 Iranian postmenopausal women. In multiple logistic regression analysis, lower osteocalcin and CrossLaps levels were associated with a higher odds ratio (OR) of having type 2 diabetes mellitus when adjustments were made for age, hs-CRP, cardiovascular risk factors, BMD, and markers of bone metabolism [OR 5.17, CI (2.66–10.04), p < 0.0001 and OR 2.51, CI (1.37–4.61), p = 0.003, respectively]. However, lower alkaline phosphatase levels were associated with a lower OR of having type 2 diabetes mellitus [OR 0.28, CI (0.15–0.52), p < 0.0001] in regression analysis. No significant difference was found between serum osteocalcin levels of those with and without metabolic syndrome. Among the metabolic syndrome components, low osteocalcin levels had significant associations with elevated blood glucose [OR 1.89, CI (1.16–3.07), p = 0.010] and elevated waist circumference [OR 2.53, CI (1.13–5.67), p = 0.024] in multivariate analyses. In conclusion, serum osteocalcin was independently associated with glucose intolerance and abdominal obesity as the components of metabolic syndrome and type 2 diabetes mellitus in postmenopausal women. Since CrossLaps and alkaline phosphatase levels were independently associated with the presence of type 2 diabetes mellitus, the unique contribution of osteocalcin in glucose metabolism could not be concluded.

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Acknowledgments

This project was supported jointly by a grant from the Ministry of Health; Tehran Endocrine Research Center; Tehran University of Medical Science, Tehran, Islamic Republic of Iran; and Bushehr Province Research Committee.

Conflict of interest

All authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Boostan 19 Alley, Imam Khomeini St, 7514763448, Bushehr, Islamic Republic of Iran

    Ali Movahed, Iraj Nabipour, Mohammadreza Kalantarhormozi, Kamyar Asadipooya, Katayoun Vahdat, Samad Akbarzadeh, Roya Amirinejad & Zahra Sanjdideh

  2. Tehran Endocrine Research Centre, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Bagher Larijani

  3. Department of Biochemistry, The Persian Gulf Marine Biotechnology Research Centre, Bushehr University of Medical Sciences, Bushehr, Islamic Republic of Iran

    Maryam Farrokhnia & Afshar Bargahi

  4. The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Islamic Republic of Iran

    Majid Assadi

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  1. Ali Movahed
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Correspondence to Iraj Nabipour.

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Movahed, A., Larijani, B., Nabipour, I. et al. Reduced serum osteocalcin concentrations are associated with type 2 diabetes mellitus and the metabolic syndrome components in postmenopausal women: the crosstalk between bone and energy metabolism. J Bone Miner Metab 30, 683–691 (2012). https://doi.org/10.1007/s00774-012-0367-z

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  • DOI: https://doi.org/10.1007/s00774-012-0367-z

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