Journal of Bone and Mineral Metabolism

, Volume 29, Issue 3, pp 328–333

The effects of intravenous zoledronic acid in Chinese women with postmenopausal osteoporosis

  • Jawl-Shan Hwang
  • Lin-Show Chin
  • Jung-Fu Chen
  • Tzay-Shing Yang
  • Po-Quang Chen
  • Keh-Sung Tsai
  • Ping Chung Leung
Original Article

DOI: 10.1007/s00774-010-0223-y

Cite this article as:
Hwang, JS., Chin, LS., Chen, JF. et al. J Bone Miner Metab (2011) 29: 328. doi:10.1007/s00774-010-0223-y

Abstract

The aim of this study was to assess the efficacy and safety of a once-yearly zoledronic acid treatment for Chinese women with postmenopausal osteoporosis in Taiwan and Hong Kong. This post hoc subpopulation analysis, from the Health Outcome and Reduced Incidence with Zoledronic Acid One Yearly Pivotal Fracture Trial, enrolled 323 Chinese women with osteoporosis who were randomly given either annual infusions of zoledronic acid or placebo for 3 consecutive years. The incidence of fractures and changes in bone mineral density (BMD) were measured; adverse events (AEs) and tolerability were recorded and assessed. The results of this study at 36 months demonstrate that there was a significantly reduced risk of morphometric vertebral fracture and clinical vertebral fracture in subjects treated with zoledronic acid (P < 0.05). In addition, there were significant increases of BMD by 4.9%, 4.3%, and 7.0% in the total hip, femoral neck, and trochanter, respectively, in the zoledronic acid group compared with the placebo group (P < 0.001 for all comparisons). The incidences of AEs were comparable between the two groups. Thus, once-yearly zoledronic acid treatment showed bone protection effects by reducing the risk of vertebral fracture and increasing BMD in Chinese women with postmenopausal osteoporosis.

Keywords

Zoledronic acidOsteoporosisBone mineral density

Copyright information

© The Japanese Society for Bone and Mineral Research and Springer 2010

Authors and Affiliations

  • Jawl-Shan Hwang
    • 1
  • Lin-Show Chin
    • 2
  • Jung-Fu Chen
    • 1
  • Tzay-Shing Yang
    • 3
  • Po-Quang Chen
    • 4
    • 5
  • Keh-Sung Tsai
    • 6
  • Ping Chung Leung
    • 7
  1. 1.Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial HospitalChang Gung UniversityKaohsiungTaiwan, ROC
  2. 2.Department of Orthopedic SurgeryChi-Mei Medical CenterTainanTaiwan, ROC
  3. 3.Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, School of MedicineNational Yang-Ming UniversityTaipeiTaiwan, ROC
  4. 4.Department of Orthopedic SurgeryMin-Sheng General HospitalTaoyuanTaiwan, ROC
  5. 5.National Taiwan University HospitalTaipeiTaiwan, ROC
  6. 6.Department of Internal Medicine, National Taiwan University Hospital, College of MedicineNational Taiwan UniversityTaipeiTaiwan, ROC
  7. 7.3/F, School of Public Health, Prince of Wales HospitalJockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong KongShatinHong Kong