Journal of Bone and Mineral Metabolism

, Volume 28, Issue 4, pp 365–383

Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons

  • Toshiyuki Yoneda
  • Hiroshi Hagino
  • Toshitsugu Sugimoto
  • Hiroaki Ohta
  • Shunji Takahashi
  • Satoshi Soen
  • Akira Taguchi
  • Satoru Toyosawa
  • Toshihiko Nagata
  • Masahiro Urade
Perspective

DOI: 10.1007/s00774-010-0162-7

Cite this article as:
Yoneda, T., Hagino, H., Sugimoto, T. et al. J Bone Miner Metab (2010) 28: 365. doi:10.1007/s00774-010-0162-7

Abstract

Bisphosphonates (BPs) have been widely, efficiently, and safely used for the treatment of osteoporosis, malignant hypercalcemia, bone metastasis of solid cancers, and multiple myeloma bone diseases. Accumulating recent reports describe that surgical dental treatments in patients with cancer or osteoporosis who have been receiving intravenous or oral BPs are associated with osteonecrosis of the jaw (bisphosphonate-related osteonecrosis of the jaw, BRONJ). The accurate incidence, clinical backgrounds, and pathogenesis of BRONJ have been unclear and appropriate approaches for prevention and treatment have not been established to date. To address the current situation of BRONJ in Japan, the “Allied Task Force Committee of Bisphosphonate-Related Osteonecrosis of the Jaw,” consisting of physicians specializing in bone biology, orthopedic surgery, rheumatology, obstetrics/gynecology, and medical oncology and dentists specializing in oral surgery, periodontology, dental radiology, and oral pathology, was organized. The committee attempted to propose a standard position paper for the treatment of BRONJ. The committee expects that this proposal will provide objective and correct scientific information on BRONJ and will serve as a reference for conducting dental procedures for patients receiving BPs and in designing prevention and treatment of BRONJ. However, because this position paper is not based on direct clinical evidence, it should be used as a reference, and a decision on treatment in each case should be made after an extensive discussion among physicians, dentists/oral surgeons, and the patients.

Keywords

Bone resorptionOsteoclastsOral bacteriaOsteomyelitisTeam care system

Copyright information

© The Japanese Society for Bone and Mineral Research and Springer 2010

Authors and Affiliations

  • Toshiyuki Yoneda
    • 1
  • Hiroshi Hagino
    • 2
  • Toshitsugu Sugimoto
    • 3
  • Hiroaki Ohta
    • 4
  • Shunji Takahashi
    • 5
  • Satoshi Soen
    • 6
  • Akira Taguchi
    • 7
  • Satoru Toyosawa
    • 8
  • Toshihiko Nagata
    • 9
  • Masahiro Urade
    • 10
  1. 1.Department of BiochemistryOsaka University Graduate School of DentistrySuitaJapan
  2. 2.School of Health Science, Faculty of MedicineTottori University HospitalYonagoJapan
  3. 3.Internal Medicine 1Shimane University Faculty of MedicineIzumoJapan
  4. 4.Department of Obstetrics and GynecologyTokyo Women’s Medical UniversityTokyoJapan
  5. 5.Division of Clinical Chemotherapy, Cancer Chemotherapy CenterJapanese Foundation for Cancer ResearchTokyoJapan
  6. 6.Department of Orthopaedic Surgery and Rheumatology, Nara HospitalKinki University School of MedicineNaraJapan
  7. 7.Department of Oral and Maxillofacial RadiologyMatsumoto Dental UniversityShiojiriJapan
  8. 8.Department of Oral PathologyOsaka University Graduate School of DentistryOsakaJapan
  9. 9.Department of Periodontology and Endodontology, Institute of Health BioscienceThe University of Tokushima Graduate SchoolTokushimaJapan
  10. 10.Department of Oral and Maxillofacial SurgeryHyogo College of MedicineHyogoJapan